PERIODONTAL CONDITION AND MICROBIOLOGY OF HEALTHY AND DISEASED PERIODONTAL POCKETS IN TYPE-1 DIABETES-MELLITUS PATIENTS
PERIODONTAL CONDITION AND MICROBIOLOGY OF HEALTHY AND DISEASED PERIODONTAL POCKETS IN TYPE-1 DIABETES-MELLITUS PATIENTS
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DOI：
10.1111/j.1600-051x.1989.tb01662.x
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发表时间：
1989-05-01
影响因子：
6.7
通讯作者：
DEGRAAFF, J
中科院分区：
文献类型：
--
作者：
SASTROWIJOTO, SH;HILLEMANS, P;DEGRAAFF, J
根据糖化血红蛋白（HbA 1c）值，将22名1型（胰岛素依赖型）糖尿病成人分为接近正常（HbA 1c ≤）的患者。7.7%）和差（HbA 1c ≥ 7.7%）。9.9%）代谢控制。共检查了44个龈下部位的伴放线放线杆菌、黑色拟杆菌属和二氧化碳嗜纤维菌属。在牙周状况方面，两个试验组的患者之间没有显著差异。 糖尿病患者的年龄和糖尿病病程均不影响牙周参数。在两个试验组中，发现4 mm或更深的囊袋深度（GEQ 4 mm）与肿胀、探诊后出血和边缘斑块量增加显著相关。可培养的A.伴放线菌（平均4.3%;范围2.8-5.8%）、牙龈拟杆菌（33.2%和34.6%）和中间拟杆菌（平均4.2%;范围0.001-13.5%）。在代谢控制不佳的糖尿病患者中，B。从患病牙周袋中分离出中间肌，平均%为7.2%，范围为0.3- 12.5%。与代谢控制程度无关，从患病和健康牙周袋中分离出的二氧化碳噬纤维菌属物种百分比较低，分别为平均0.9%（范围0.003-3.9%）和平均1.4%（范围0.04-4.9%）。从这项研究中得出结论，代谢控制似乎对牙周组织没有直接影响。此外，二氧化碳噬纤维菌属在I型糖尿病患者感染性牙周病发病机制中的作用似乎被高估了。然而，A.放线菌共生菌和黑色拟杆菌属物种可能是I型糖尿病患者牙周病的重要病原体，因为已知它们在非糖尿病牙周病患者中是重要病原体。
On the basis of glycosylated hemoglobin (HbA1c) values, 22 type 1 (insulin-dependent) diabetic adults were grouped into patients with near normal (HbA1c .ltoreq. 7.7%) and poor (HbA1c .gtoreq. 9.9%) metabolic control. A total of 44 subgingival sites were examined for Actinobacillus actinomycetemcomitans, black-pigmented Bacteroides species and Capnocytophaga species. No significant difference could be demonstrated between patients in the 2 test groups with regard to periodontal condition. Neither age of diabetic patients nor duration of diabetes mellitus influenced the periodontal parameters. In both test groups, pocket depth of 4 mm or more [GEQ 4mm) was found to be significantly associated with increased welling, bleeding after probing and amount of marginal plaque. Proportionally high % of cultivable A. actinomycetemcomitans (mean 4.3%; range 2.8-5.8%), Bacteroides gingivalis (33.2% and 34.6%) and Bacteroides intermedius (mean 4.2%; range 0.001-13.5%) were isolated from diseased periodontal pockets. In diabetic patients with poor metabolic control, B. intermedius was isolated from diseased periodontal pockets with a mean % of 7.2%, range 0.3-12.5%. Independent of the degree of metabolic control, low % of Capnocytophaga species were isolated from diseased and healthy periodontal pockets, mean 0.9% (range 0.003-3.9%) and mean 1.4% (range 0.04-4.9%), respectively. It was concluded from this study that metabolic control seems to have no direct effect on the periodontium. Furthermore, the role of Capnocytophaga species in the pathogenesis of infectious periodontal disease in type I diabetic patients seems to be overestimated. However, A. actinomycetemcomitans and blackpigmented Bacteroides species may be important pathogens in periodontal disease in type I diabetic patients, as they are known to be in non-diabetic periodontal patients.