Synthesis and characterization of poly(p-dioxanone)-based degradable copolymers with enhanced thermal and hydrolytic stabilities
Synthesis and characterization of poly(p-dioxanone)-based degradable copolymers with enhanced thermal and hydrolytic stabilities
复制标题
DOI：
10.1016/j.cclet.2021.08.124
复制
发表时间：
2021-09
影响因子：
9.1
通讯作者：
Yihan Yan;Gang Wu;Si-chong Chen;Yu-Zhong Wang
中科院分区：
文献类型：
--
作者：
Yihan Yan;Gang Wu;Si-chong Chen;Yu-Zhong Wang
本文报道了一种新型的可生物降解的聚对二氧环己酮-聚2-（2-羟基乙氧基）苯甲酸酯（PPDO-co-PDHB）预聚物与HDI的扩链反应。通过核磁共振氢谱（1H NMR）和粘度测试表征了PPDO-co-PDHB预聚体和PPDO-co-PDHB-PU扩链共聚物的结构和分子量。建立了扩链共聚物的分子结构与性能之间的关系。与PPDO均聚物相比，PPDO-co-PDHB-PU共聚物具有更好的热稳定性。力学性能研究表明，PPDO-co-PDHB-PU的断裂伸长率比PPDO高得多。水解降解行为的研究表明，PPDO的降解速率可以通过调节PDHB的组成来控制，扩链共聚物的水解稳定性优于PPDO。
Herein, we presented a novel biodegradable copolymerviathe chain extending reaction of poly(p-dioxanone)-co-poly(2-(2-hydroxyethoxy) benzoate) (PPDO-co-PDHB) prepolymer with hexamethylene diisocyanate (HDI) as a chain extender. The structures and molecular weight of PPDO-co-PDHB prepolymer and PPDO-co-PDHB-PU chain-extended copolymer are characterizedviahydrogen nuclear magnetic resonance spectroscopy (1H NMR) and viscosity test. The relationship between the molecular structures and properties of the chain-extended copolymers is established. The PPDO-co-PDHB-PU copolymers possess a better thermal stability comparing with the PPDO homopolymer. The study of mechanical properties shows that the elongation-at-break of PPDO-co-PDHB-PU is much higher than that of PPDO. The investigation of hydrolytic degradation behaviors indicates the degradation rate of PPDO can be controlled by adjusting the PDHB compositions, and proves that chain-extended copolymers exhibit an excellent hydrolytic stability being better than that of PPDO.