Reproducibility of rectal tumor volume delineation using diffusion-weighted MRI: Agreement on volumes between observers
Reproducibility of rectal tumor volume delineation using diffusion-weighted MRI: Agreement on volumes between observers
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DOI：
10.1016/j.canrad.2018.10.004
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发表时间：
2019-06-01
影响因子：
1.3
通讯作者：
Genovesi, D.
中科院分区：
文献类型：
--
作者：
Rosa, C.;Caravatta, L.;Genovesi, D.
目的。回顾性评价放疗医师和放射肿瘤学家之间的观察者之间的一致性，以及直肠癌患者总肿瘤体积（GTV）划定的T2和弥散加权（DWI） MRI的体积差异。材料和方法。两名观察员，一名放射科医生和一名放射肿瘤学家，通过T2加权MRI （T2(GTV)）和回波平面DWI （DWIGTV）描绘了50名患者的GTV。采用DICE指数、Bland -Altman分析和类内相关系数（ICC）评估观察者的一致性。GTV比较采用学生t检验。放射科医生的中位T2（GTV）和DWIGTV分别为17.09 +/- 14.12 cm(3)（1.92-62.03）和12.79 +/- 12.31 cm(3)(1.23-62.25)，放射肿瘤科医生的中位T2（GTV）和DWIGTV分别为16.82 +/- 13.66 cm(3)（1.78-65.9）和13.72 +/- 12.77 cm(3)（1.29-69.75）。T2（GTV）明显大于DWIGTV （P< 0.001和P< 0.001）。T2（GTV）和DWIGTV的平均DICE指数分别为0.80 +/- 0.07和0.77 +/- 0.06。T2和DWI体积的平均差异为0.26 cm(3) （95% CI: -5.36至5.88）和-1.13 cm(3) （95% CI: -5.70至3.44）。T2体积的ICC为0.989 (95% CI: 0.981 ~ 0.994) (P < 0.001)， DWI体积的ICC为0.992 (95% CI: 0.986 ~ 0.996) （P < 0.001）。-与t2加权MRI相比，DWI导致更小的体积描绘。放射科医师和放射肿瘤学家对DWIGTV和T2（GTV）的评估结果基本一致。由于DWI可以被认为是放射肿瘤学家的一种简单的体积描绘技术，当研究剂量递增时，DWI可以用于提高辐射计划的质量，以准确地描绘增强体积。(C) 2019法国放射治疗肿瘤学会（SFRO）。Elsevier Masson SAS出版。版权所有。
Purpose. - To retrospectively evaluate the inter -observer agreement between a radiologist and a radiation oncologist and volume differences, in T2 and diffusion -weighted (DWI) MRI of gross tumor volume (GTV) delineation, in rectal cancer patients.Materials and methods. - Two observers, a radiologist and a radiation oncologist, delineated GTVs of 50 patients on T2-weighted MRI (T2(GTV)) and echo planar DWI (DWIGTV). Observers agreement was assessed using DICE index, Bland -Altman analysis and intra-class correlation coefficient (ICC). Student's t-test was used for GTV comparison.Results. - Median T2(GTV) and DWIGTV were 17.09 +/- 14.12 cm(3) (1.92-62.03) and 12.79 +/- 12.31 cm(3) (1.23-62.25) for radiologist, and 16.82 +/- 13.66 cm(3) (1.78-65.9) and 13.72 +/- 12.77 cm(3) (1.29-69.75) for radiation oncologist. T2(GTV) were significantly larger compared to DWIGTV (P< 0.001 and P < 0.001, for both observers). Mean DICE index for T2(GTV) and DWIGTV were 0.80 +/- 0.07 and 0.77 +/- 0.06. The mean difference between the two observers were 0.26 cm(3) (95% CI: -5.36 to 5.88) and -1.13 cm(3) (95% CI: -5.70 to 3.44) for T2 and DWI volumes. The ICC for T2 volumes was 0.989 (95% CI: 0.981-0.994) (P < 0.001) and 0.992 (95% CI: 0.986-0.996) (P < 0.001) for DWI volumes.Conclusion. - DWI resulted in smaller volumes delineation compared to T2-weighted MRI. Substantial and almost perfect agreements were reported for DWIGTV and T2(GTV) between radiologist and radiation oncologist. Due to the fact that DWI could be considered a simple technique for volume delineation for radiation oncologist, DWI could be used to improve quality in radiation planning for an accurate boost volume delineation when a dose escalation is investigated. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.