daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.
daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.
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发表时间：
1998-04
期刊：
影响因子：
4.6
通讯作者：
Adam Antebi;J. Culotti;E. Hedgecock
中科院分区：
文献类型：
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作者：
Adam Antebi;J. Culotti;E. Hedgecock
从卵到成虫，秀丽隐杆线虫有六个生命阶段，其中包括在不利环境下形成水和幼虫阶段L3的滞育。整个生物体的体细胞做出一致的选择并一致地前进，这表明在这些阶段转变中存在协调调节机制。早期的研究表明，编码核受体的daf-12 (W. Yeh, 1991，博士论文。密苏里-哥伦比亚大学（University of Missouri-Columbia）)，调控水的形成；上位性实验将daf-12置于dwer信号通路的末端。在这里，我们描述了新的daf-12等位基因，揭示了在推进L3阶段项目中的一般作用。在这些突变体中，体细胞在L3阶段重复l2特异性的细胞分裂和迁移程序；上位性实验将daf-12置于异慢性通路的lin-14和lin-28之间。我们认为daf-12和其他异时基因为选择适合发育阶段的发育程序提供了时间阶段的细胞记忆。内分泌因素可以协调这些阶段的转变，并指定发展的选择。
From egg through adult, C. elegans has six life stages including an option for dauer formation and diapause at larval stage L3 in adverse environments. Somatic cells throughout the organism make consistent choices and advance in unison, suggesting a mechanism of coordinate regulation at these stage transitions. Earlier studies showed that daf-12, which encodes a nuclear receptor (W. Yeh, 1991, Doctoral Thesis. University of Missouri-Columbia), regulates dauer formation; epistasis experiments placed daf-12 near the end of the dauer signaling pathway. Here we describe novel daf-12 alleles that reveal a general role in advancing L3 stage programs. In these mutants, somatic cells repeat L2-specific cellular programs of division and migration at the L3 stage; epistasis experiments place daf-12 between lin-14 and lin-28 within the heterochronic pathway. We propose daf-12 and other heterochronic genes provide cellular memories of chronological stage for selecting stage-appropriate developmental programs. Endocrine factors could coordinate these stage transitions and specify developmental alternatives.