IDENTIFICATION OF NEW METABOLITES OF BUTYLATED HYDROXYTOLUENE (BHT) IN RATS
IDENTIFICATION OF NEW METABOLITES OF BUTYLATED HYDROXYTOLUENE (BHT) IN RATS
复制标题
大鼠中丁基羟基甲苯 (BHT) 新代谢物的鉴定
DOI：
10.1248/bpb1978.2.164
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
T. Mizutani
中科院分区：
文献类型：
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作者：
Kenji Yamamoto;K. Tajima;T. Mizutani
雄性Wistar大鼠腹腔注射丁基羟基甲苯（BHT）后，通过气相色谱法显示了该化合物的三种新代谢产物的尿和粪便排泄。通过与真实样品的气相色谱和质谱数据比较，鉴定了这些代谢产物2，6-二叔丁基对苯醌（M-I）、2，6-二叔丁基对苯二酚（M-II）和2，6-二叔丁基-4-[（甲硫基）甲基]苯酚（M-III）的结构。还讨论了作为中间代谢物的2，6-二叔丁基-4-氢过氧基-4-甲基-2，5-环己二烯-1-酮（1）的可能形成，以解释M-I的发生。
The urinary and fecal excretion of three new metabolites of butylated hydroxytoluene (BHT) were revealed by gas chromatography after intraperitoneal administration of this compound to male Wistar rats. The structures of these metabolites, 2, 6-di-tert-butyl-p-benzoquinone (M-I), 2, 6-di-tert-butylhydroquinone (M-II), and 2, 6-di-tert-butyl-4-[(methylthio) methyl] phenol (M-III), were identified by comparison of gas chromatographic and mass spectral data with those of authentic samples. The possible formation of 2, 6-di-tert-butyl-4-hydroperoxy-4-methyl-2, 5-cyclohexadien-1-one (1) as an intermediary metabolite to account for the occurrence of M-I was also discussed.