Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase
Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase
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DOI：
10.1021/ol0625233
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发表时间：
2006-12-21
期刊：
影响因子：
5.2
通讯作者：
Noguchi, Hiroshi
中科院分区：
文献类型：
--
作者：
Abe, Ikuro;Abe, Tsuyoshi;Noguchi, Hiroshi
来自掌叶大黄的苄叉丙酮合酶有效催化N-甲基邻氨基苯甲酰-CoA（或邻氨基苯甲酰-CoA）与丙二酰-CoA（或甲基丙二酰-CoA）的缩合以产生4-羟基-2（1H）-喹诺酮，这是由III型聚酮合酶（PKS）产生的新型杀菌支架。因此，通过非生理底物操纵功能上不同的III型PKS提供了一种生产药学上重要的喹诺酮生物碱的有效方法。
Benzalacetone synthase from Rheum palmatum efficiently catalyzed condensation of N-methylanthraniloyl-CoA (or anthraniloyl-CoA) with malonyl-CoA (or methylmalonyl-CoA) to produce 4-hydroxy-2(1H)-quinolones, a novel alkaloidal scaffold produced by a type III polyketide synthase (PKS). Manipulation of the functionally divergent type III PKSs by a nonphysiological substrate thus provides an efficient method for production of pharmaceutically important quinolone alkaloids.