The Effects of Unfractionated Heparin on Survival in Patients with Malignancy – A Systematic Review
The Effects of Unfractionated Heparin on Survival in Patients with Malignancy – A Systematic Review
复制标题
普通肝素对恶性肿瘤患者生存的影响——系统评价
作者：
Susanne M. Smorenburg;Rohan J. K. Hettiarachchi;R. Vink;H. Büller
临床和实验研究表明，普通肝素（UFH）影响恶性肿瘤的进展。我们回顾了所有已发表的关于UFH对癌症患者生存影响的临床报告，并与未治疗的癌症患者进行了比较。根据方法学强度对研究进行分类，并根据是否使用UFH的治疗或预防剂量进行细分。提取或计算3年后的死亡率。一项评估小细胞肺癌患者使用治疗剂量UFH的随机研究报告了生存率的改善（比值比（OR）0.64; 95%置信区间（CI）：0.25至1.62）。在2项随机研究中观察到有害作用，这些研究调查了胃肠道癌术后门静脉内UFH预防剂量治疗的效果（OR 1.66; 95% CI：1.02 - 2.71）。相反，2级研究评价了UFH治疗或预防剂量对胃肠道癌患者死亡率的影响，OR分别为0.58（95%CI; 0.11-3.13）和0.65（95%CI 0.51 - 0.84）。我们的结论是，没有令人信服的证据，无论是积极或消极的影响，UFH对恶性肿瘤患者的生存。哈里河Büller是荷兰心脏基金会的资深研究员
Summary Clinical and experimental studies have suggested that unfractionated heparin (UFH) effects malignancy progression. We reviewed all published clinical reports concerning the effects of UFH, as compared to no treatment on survival of cancer patients. Studies were classified on methodological strength and subdivided as to whether therapeutic or prophylactic dosages of UFH were used. Mortality rates after 3 years were extracted or calculated. One randomized study that evaluated the use of UFH in therapeutic dosages in patients with small cell lung carcinoma reported on an improved survival (odds ratio (OR) 0.64; 95% confidence interval (CI): 0.25 to 1.62). A detrimental effect was observed in 2 randomized studies which investigated the effects of intraportal UFH treatment in a prophylactic dose after surgery for gastrointestinal cancer (OR 1.66; 95% CI: 1.02 to 2.71). In contrast, level 2 studies in which either therapeutic or prophylactic dosages of UFH on mortality of patients with gastrointestinal cancer were evaluated, showed OR of 0.58 (95% CI; 0.11-3.13) and 0.65 (95% CI 0.51 to 0.84), respectively. We conclude that there is no convincing evidence of either positively or negatively effects of UFH on survival of patients with malignancy. Harry R. Büller is an Established Investigator of the Dutch Heart Foundation
影响因子：
45.3
作者：
CHAHINIAN, AP;PROPERT, KJ;GREEN, MR
通讯作者：
GREEN, MR