ALCOHOL, SMOKING AND CANCER OF THE UPPER AERODIGESTIVE TRACT - A PROSPECTIVE-STUDY AMONG HAWAII JAPANESE MEN
ALCOHOL, SMOKING AND CANCER OF THE UPPER AERODIGESTIVE TRACT - A PROSPECTIVE-STUDY AMONG HAWAII JAPANESE MEN
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DOI：
10.1002/ijc.2910600508
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发表时间：
1995-03-03
影响因子：
6.4
通讯作者：
STEMMERMANN, GN
中科院分区：
文献类型：
--
作者：
CHYOU, PH;NOMURA, AMY;STEMMERMANN, GN
对1965年至1968年接受采访和检查的7，995名日裔美国男性进行了上呼吸消化道癌症的队列研究。收集有关吸烟史、饮酒和饮食摄入的信息。24年后，确定了92例经组织学确诊的病例。在检查时，目前吸烟者患上呼吸消化道癌的风险是从不吸烟者的3倍。随着吸烟量的增加和持续时间的延长，存在剂量-反应关系。饮用啤酒、葡萄酒、烈酒和总酒精与风险增加密切相关。在23种食品和饮料类别中，只有糖果/果冻/汽水消费量出现了统计学上显著的反向趋势。经常食用水果也与这种癌症呈负相关。相比之下，这种风险往往与食用大米、海藻、豆腐或tsukuanani（一种鱼、糖、酱料和海藻的混合菜）呈正相关，但剂量-反应关系在统计学上并不显著。对于营养摄入，增加钙和脂肪的摄入量可以降低患这种癌症的风险。(C)1995年Wiley-Liss，Inc.
A cohort study of upper aerodigestive tract cancer was conducted among 7,995 Japanese-American men who were interviewed and examined from 1965 to 1968. Information was collected about smoking history and alcohol and dietary intake. After 24 years, 92 incident cases with histological confirmation of diagnosis were identified. Current cigarette smokers at time of examination had a 3-fold risk for upper aerodigestive tract cancer compared with never-smokers. A dose-response relationship was present with increasing amount and duration of cigarette use. Consumption of beer, wine, spirits and total alcohol was strongly associated with increased risk. Of 23 food and beverage categories, only candy/jelly/soda pop consumption had a statistically significant inverse trend. Frequent consumption of fruit was also inversely associated with this cancer. In contrast, the risk tended to be positively associated with consumption of rice, seaweed, tofu or tsukudani (a mixed dish of fish, sugar, soy sauce and seaweed), but the dose-response relationship was not statistically significant. For nutrient intake, increased calcium and fat intake decreased the risk for this cancer. (C) 1995 Wiley-Liss, Inc.