Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly
Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly
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DOI：
10.1016/j.jagp.2016.03.001
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发表时间：
2016-08-01
影响因子：
7.2
通讯作者：
Lee, Dong Young
中科院分区：
文献类型：
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作者：
Choi, Hyo Jung;Byun, Min Soo;Lee, Dong Young
目的：尽管许多临床前研究表明血脂异常与脑淀粉样蛋白沉积之间可能存在联系，但血脂水平与脑内淀粉样β蛋白(Aβ)沉积之间的关系仍知之甚少。我们的目标是在认知正常(CN)的老年人中调查这种关联。设计：横断面研究。单位：大学医院痴呆症门诊。对象：59名CN老年人。测量：研究测量包括基于CERAD方案的全面临床和神经心理评估、磁共振成像和C-11标记的匹兹堡化合物B正电子发射断层扫描，以及血清脂质生物标志物的量化。结果：多元线性回归分析显示，即使在控制了年龄、性别和载脂蛋白E epsilon 4基因后，血清甘油三酯水平越高，脑组织Aβ沉积越重。血清载脂蛋白B与全脑Aβ沉积也呈显著正相关，但在控制血清甘油三酯水平后，这种相关性消失。未发现其他血脂指标与整体脑组织Aβ沉积之间的关联。结论：这些发现表明血清甘油三酯与脑淀粉样变性密切相关，尽管还需要基于人群的前瞻性研究来提供甘油三酯对脑淀粉样变性的致病作用的进一步证据。
Objectives: Although many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (A beta) deposition in human brain is still poorly known. We aimed to investigate the association in cognitively normal (CN) elderly individuals. Design: Cross-sectional study. Setting: University hospital dementia clinic. Participants: 59 CN elderly. Measurements: The study measures included comprehensive clinical and neuropsychological assessment based on the CERAD protocol, magnetic resonance imaging and C-11-labelled Pittsburgh Compound B positron emission tomography scans, and quantification for serum lipid biomarkers. Results: Multiple linear regression analyses showed that a higher serum triglycerides level was associated with heavier global cerebral A beta deposition even after controlling age, sex, and apolipoprotein E epsilon 4 genotype. Serum apolipoprotein B also showed significant positive association with global cerebral A beta deposition, but the significance disappeared after controlling serum triglycerides level. No association was found between other lipid measures and global cerebral A beta deposition. Conclusions: The findings suggest that serum triglycerides are closely associated with cerebral amyloidosis, although population-based prospective studies are needed to provide further evidence of the causative effect of triglycerides on cerebral amyloidosis.