The ENCODE Blacklist: Identification of Problematic Regions of the Genome
The ENCODE Blacklist: Identification of Problematic Regions of the Genome
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DOI：
10.1038/s41598-019-45839-z
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发表时间：
2019-06-27
影响因子：
4.6
通讯作者：
Boyle, Alan P.
中科院分区：
文献类型：
--
作者：
Amemiya, Haley M.;Kundaje, Anshul;Boyle, Alan P.
基于高通量测序的功能基因组学分析极大地扩展了我们理解基因组的能力。在这里，我们定义了ENCODE黑名单-人类，小鼠，蠕虫和苍蝇基因组中的一组综合区域，这些区域在独立于细胞系或实验的下一代测序实验中具有异常，非结构化或高信号。删除ENCODE黑名单是分析功能基因组学数据时必不可少的质量措施。
Functional genomics assays based on high-throughput sequencing greatly expand our ability to understand the genome. Here, we define the ENCODE blacklist- a comprehensive set of regions in the human, mouse, worm, and fly genomes that have anomalous, unstructured, or high signal in next-generation sequencing experiments independent of cell line or experiment. The removal of the ENCODE blacklist is an essential quality measure when analyzing functional genomics data.