Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties
Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties
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DOI：
10.1016/j.sbi.2014.06.001
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发表时间：
2014-06-01
影响因子：
6.8
通讯作者：
Levy, Emmanuel D.
中科院分区：
文献类型：
--
作者：
Matalon, Or;Horovitz, Amnon;Levy, Emmanuel D.
异源寡聚蛋白复合物参与细胞中的许多关键过程。鉴于复杂功能的亚基共同发挥作用，人们通常期望发现（i）它们在细胞中以相似的水平表达； (ii) 它们同时存在或不存在于基因组中； (iii) 删除其基因对适应性的影响应该是相似的。然而，这种一致性常常很弱或不存在。亚基的多功能性和复杂组装的机制被讨论为缺乏一致性的可能根源。
Hetero-oligomeric protein complexes are involved in many of the key processes in cells. Given that the subunits of a complex function together, it has often been expected to find that (i) they are expressed at similar levels in cells; (ii) they are simultaneously present or absent in genomes; and that (iii) the effects on fitness of deleting their genes should be similar. Such a coherence is, however, often found to be weak or absent. Multi-functionality of subunits and mechanisms of complex assembly are discussed as possible sources for the lack of coherence.