Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling
Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling
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DOI：
10.1038/ni.1672
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发表时间：
2008-12-01
影响因子：
30.5
通讯作者：
Tan, Man-Wah
中科院分区：
文献类型：
--
作者：
Kawli, Trupti;Tan, Man-Wah
免疫系统和神经系统之间的交流，每个系统都能够对环境刺激迅速作出反应，可能会带来生存优势。然而，神经系统如何影响免疫反应以及神经调节免疫功能是否具有生物学重要性尚不清楚。在这里，我们报告说，神经元胞吐的神经肽从致密的核心囊泡抑制秀丽隐杆线虫的生存和清除感染的人类细菌病原体铜绿假单胞菌。这种免疫调节功能是介导的INS-7，胰岛素样神经肽，其诱导与假单胞菌的毒力。神经系统分泌的INS-7以非细胞自主的方式激活胰岛素途径，改变肠细胞中免疫相关基因的基础和诱导表达。
Communication between the immune and nervous systems, each of which is able to react rapidly to environmental stimuli, may confer a survival advantage. However, precisely how the nervous system influences the immune response and whether neural modulation of immune function is biologically important are not well understood. Here we report that neuronal exocytosis of neuropeptides from dense core vesicles suppressed the survival of Caenorhabditis elegans and their clearance of infection with the human bacterial pathogen Pseudomonas aeruginosa. This immunomodulatory function was mediated by INS-7, an insulin-like neuropeptide whose induction was associated with Pseudomonas virulence. INS-7 secreted from the nervous system functioned in a non-cell autonomous way to activate the insulin pathway and alter basal and inducible expression of immunity-related genes in intestinal cells.