Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations.
Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations.
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DOI：
10.1016/j.bone.2011.07.010
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发表时间：
2011-10
期刊：
影响因子：
4.1
通讯作者：
Wehrli, Felix W.
中科院分区：
文献类型：
--
作者：
Lam, Shing Chun Benny;Wald, Michael J.;Rajapakse, Chamith S.;Liu, Yinxiao;Saha, Punam K.;Wehrli, Felix W.
序列重复性和可靠性关键决定了检测干预反应变化的敏感性，并为样本量估计提供了基础。在这里，我们评估了20名年龄在50到75岁(平均为62.0岁，S.D.=8.1a)的女性，在药物干预试验和骨折研究中具有代表性的研究人群中，基于MRI的虚拟骨活检的26个结构和力学参数的性能。受试者用1.5T场强，体素大小为137×137×410μm~3，平均间隔20.2d(S.D.=14.5d)进行3次检查。方法包括前瞻性和回溯性3D图像配准和自动聚焦运动校正。分析是从中央的5×5×5mm3长方体和小梁体积进行的，小梁体积由一个13 mm的轴向平板组成，包围整个髓腔。通过有限元分析计算了整体体积的轴向刚度、分区域的杨氏模数和剪切模数。所有结构参数的总体平均变异系数为4.4%(1.8%~7.7%)，轴向刚度为4.0%；子体积内相应的结构参数变异系数为6.5%(1.6%~13.0%)，力学参数变异系数为5.5%(4.6%~6.5%)。对于全体积衍生的结构参数和轴向刚度，总的ICC值分别为0.976(0.947~0.986)和0.992；对于亚体积衍生的结构参数和力学参数，总的ICC分别为0.946(0.752~0.991)和0.974(0.965~0.978)。全容积轴向刚度的预测因子为BV/Tv、结合部密度、骨密度和Tb.N(R2为0.79~0.87)。同样的参数对次区域轴向弹性系数也有很高的预测性(R2为0.88-0.91)。这些数据表明，该方法适用于治疗反应的纵向评估。基础技术是便携的，应该与所有通用核磁共振扫描仪兼容，考虑到这种设备的安装基数非常大，这一点很有吸引力。
Serial reproducibility and reliability critically determine sensitivity to detect changes in response to intervention and provide a basis for sample size estimates. Here, we evaluated the performance of the MRI-based Virtual Bone Biopsy in terms of 26 structural and mechanical parameters in the distal radius of 20 women in the age range of 50 to 75 years (mean = 62.0 years, S.D. = 8.1 years), representative of typical study populations in drug intervention trials and fracture studies. Subjects were examined three times at average intervals of 20.2 days (S.D. = 14.5 days) by MRI at 1.5 T field strength at a voxel size of 137×137×410 μm3. Methods involved prospective and retrospective 3D image registration and auto-focus motion correction. Analyses were performed from a central 5×5×5 mm3 cuboid subvolume and trabecular volume consisting of a 13 mm axial slab encompassing the entire medullary cavity. Whole-volume axial stiffness and sub-regional Young’s and shear moduli were computed by finite-element analysis. Whole-volume-derived aggregate mean coefficient of variation of all structural parameters was 4.4% (range 1.8% to 7.7%) and 4.0% for axial stiffness; corresponding data in the subvolume were 6.5% (range 1.6% to 13.0%) for structural, and 5.5% (range 4.6% to 6.5%) for mechanical parameters. Aggregate ICC was 0.976 (range 0.947 to 0.986) and 0.992 for whole-volume-derived structural parameters and axial stiffness, and 0.946 (range 0.752 to 0.991) and 0.974 (range 0.965 to 0.978) for subvolume-derived structural and mechanical parameters, respectively. The strongest predictors of whole-volume axial stiffness were BV/TV, junction density, skeleton density and Tb.N (R2 0.79 – 0.87). The same parameters were also highly predictive of sub-regional axial modulus (R2 0.88 – 0.91). The data suggest that the method is suited for longitudinal assessment of the response to therapy. The underlying technology is portable and should be compatible with all general-purpose MRI scanners, which is appealing considering the very large installed base of this modality.
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影响因子：
6.2
作者：
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