IMMUNOLOGICAL ABNORMALITIES IN MYELODYSPLASTIC SYNDROMES .1. SERUM IMMUNOGLOBULINS AND AUTOANTIBODIES
IMMUNOLOGICAL ABNORMALITIES IN MYELODYSPLASTIC SYNDROMES .1. SERUM IMMUNOGLOBULINS AND AUTOANTIBODIES
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DOI：
10.1111/j.1365-2141.1986.tb07504.x
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发表时间：
1986-05-01
影响因子：
6.5
通讯作者：
COPPLESTONE, JA
中科院分区：
文献类型：
--
作者：
MUFTI, GJ;FIGES, A;COPPLESTONE, JA
本文分析了104例原发性骨髓增生异常综合征（MDS）患者的免疫球蛋白水平和自身抗体谱。8例患者，4例共存非霍奇金淋巴瘤，3例慢性淋巴细胞白血病和1例淋巴浆细胞瘤，被排除在免疫球蛋白水平的最终分析。血清蛋白电泳和免疫电泳显示12例（12.5%）存在单克隆革兰氏病。在其余84例患者中，27例（32%）血清免疫球蛋白多克隆升高，而另外16例（19%）免疫球蛋白水平较低。直接抗球蛋白试验阳性的98例患者中有8例（8.1%），和器官和非器官特异性自身抗体存在于15个测试的67例患者（22.3%）。2例患者伴有恶性贫血（PA），2例甲状腺功能减退症，1例PA伴甲状腺功能减退症。三名患者患有血清阴性类风湿性关节炎。这些结果表明，MDS中免疫异常的发生率很高。
The immunoglobin levels and autoantibody profiles of 104 patients with primary myelodysplastic syndromes (MDS), classified according to the FAB criteria, were analysed. Eight patients, four with coexistent non-Hodgkin''s lymphomas, three with chronic lymphocytic leukaemia and one with a lymphoplasmacytoma, were excluded from the final analysis of immunoglobulin levels. Serum protein electrophoresis and immunoelectrophoresis revealed the presence of monoclonal grammopathy in 12 patients (12.5%). Of the remaining 84 patients, a polyclonal rise in serum immunoglobulins was present in 27 (32%) while a further 16 (19%) had low immunoglobulin levels. The direct antiglobulin test was positive in eight out of 98 patients tested (8.1%), and organ and non-organ specific autoantibodies were present in 15 out of 67 patients tested (22.3%). Two patients had associated pernicious anaemia (PA), two hypothyroidism, and one PA with hypothyroidism. Three patients had sero-negative rheumatoid arthritis. These results demonstrate that there is a high incidence of immunological abnormalities in MDS.