Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients:: Anomalies in the default network
Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients:: Anomalies in the default network
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DOI：
10.1093/schbul/sbm052
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发表时间：
2007-07-01
影响因子：
6.6
通讯作者：
Williamson, Peter
中科院分区：
文献类型：
--
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
血氧水平依赖（BOLD）功能性磁共振成像（MRI）信号的自发低频波动已被证明反映了大脑区域之间的神经同步性。一个自发低频波动的“默认网络”已经在健康志愿者中被描述为在刺激独立的思想。与这个网络负相关的是在需要注意力的任务中激活的区域。这两个网络都涉及到在以前的研究中与精神分裂症有关的大脑区域和功能。本研究探讨自发缓慢波动的BOLD信号在休息时，作为测量的相关性与低频振荡的后扣带回，在17名精神分裂症患者，和17名健康志愿者。健康志愿者表现出自发的低频波动的BOLD信号在后扣带回和波动的外侧顶叶，内侧前额叶和小脑区域之间的相关性，类似于以前的报告。精神分裂症患者的自发慢活动之间的相关性显着降低扣带回后，在外侧顶叶，内侧前额叶，小脑区域。后扣带回的连接性被发现在精神分裂症患者中随着阳性和阴性症状而变化。由于这些数据表明精神分裂症患者静息态神经网络存在显著异常，因此在这一人群中，BOLD信号自发缓慢波动的进一步研究似乎是必要的。
Spontaneous low-frequency fluctuations in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (MRI) signal have been shown to reflect neural synchrony between brain regions. A "default network" of spontaneous low-frequency fluctuations has been described in healthy volunteers during stimulus-independent thought. Negatively correlated with this network are regions activated during attention-demanding tasks. Both these networks involve brain regions and functions that have been linked with schizophrenia in previous research. The present study examined spontaneous slow fluctuations in the BOLD signal at rest, as measured by correlation with low-frequency oscillations in the posterior cingulate, in 17 schizophrenic patients, and 17 comparable healthy volunteers. Healthy volunteers demonstrated correlation between spontaneous low-frequency fluctuations of the BOLD signal in the posterior cingulate and fluctuations in the lateral parietal, medial prefrontal, and cerebellar regions, similar to previous reports. Schizophrenic patients had significantly less correlation between spontaneous slow activity in the posterior cingulate and that in the lateral parietal, medial prefrontal, and cerebellar regions. Connectivity of the posterior cingulate was found to vary with both positive and negative symptoms in schizophrenic patients. Because these data suggest significant abnormalities in resting-state neural networks in schizophrenia, further investigations of spontaneous slow fluctuations of the BOLD signal seem warranted in this population.