Urinary trace elements in association with premature ovarian insufficiency and reproductive hormones in a Chinese population
Urinary trace elements in association with premature ovarian insufficiency and reproductive hormones in a Chinese population
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中国人群尿液微量元素与卵巢早衰和生殖激素的关系
DOI：
10.1016/j.ecoenv.2021.112731
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发表时间：
2021
影响因子：
6.8
通讯作者：
Zhou Jianhong
中科院分区：
文献类型：
--
作者：
Li Chunming;Ma LinJuan;Qi Tongyun;Pan Wuye;Huang Yizhou;Luo Jie;Ye Xiaoqing;Lan Yibing;Liu Jing;Zhou Wenchao;Ruan Fei;Zhou Jianhong
微量元素稳态紊乱与不良生殖后果有关，包括女性卵巢早衰（POI），但迄今为止报道的证据有限。这项病例对照研究评估了 5 种常见尿液微量元素 [铜 (Cu)、锰 (Mn)、铁 (Fe)、硒 (Se) 和锌 (Zn)] 与 POI 发生几率之间的关联。检测了169例病例和209名健康对照者的尿液中这5种金属的浓度以及POI相关生殖激素的血清水平。 POI 女性尿液中铜和硒的水平显着高于对照组。在 Cu 水平和 POI 几率之间观察到正相关[对于中等三分位数：优势比 (OR) = 3.79，95% CI：1.98–7.27，p < 0.001；对于最高三分位数：OR = 3.85，95% CI：2.00–7.41，p< 0.001]。尿硒水平的最高三分位数与 POI 风险增加相关（最高三分位数：OR = 2.54，95% CI：1.38–4.70，与最低三分位数相比，趋势 p = 0.001）。在 POI 患者中，尿中锌和铁的浓度与血清促卵泡激素 (FSH) 水平呈负相关。我们的研究结果表明，较高的铜和硒暴露水平可能会导致 POI 风险增加。
Homeostasis disturbance of trace elements has been linked to adverse reproductive consequences, including premature ovarian insufficiency (POI) in women, but limited evidence has been reported so far. This case-control study evaluated the associations between 5 common urinary trace elements [copper (Cu), manganese (Mn), Iron (Fe), Selenium (Se), and zinc (Zn)] and the odds for POI. Urinary concentrations of these 5 metals and serum levels of POI-related reproductive hormones of 169 cases and 209 healthy controls were measured. The urinary levels of Cu and Se in women with POI were significantly higher than those in the controls. The positive associations were observed between Cu levels and the odds of POI [for the medium tertile: odds ratio (OR) = 3.79, 95% CI: 1.98–7.27,p< 0.001; for the highest tertile: OR = 3.85, 95% CI: 2.00–7.41,p< 0.001]. The highest tertile of urinary Se levels was associated with increasing POI risk (for the highest tertile: OR = 2.54, 95% CI: 1.38–4.70, compared with the lowest tertile,pfor trend = 0.001). In POI patients, urinary concentrations of Zn and Fe were negatively associated with serum levels of follicle-stimulating hormone (FSH). Our findings suggested that higher exposure levels of Cu and Se might lead to an increased risk of POI.