Maternal inheritance of circulating irisin in humans
Maternal inheritance of circulating irisin in humans
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DOI：
10.1042/cs20130426
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发表时间：
2014-06-01
期刊：
影响因子：
6
通讯作者：
Chrousos, George P.
中科院分区：
文献类型：
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作者：
Al-Daghri, Nasser M.;Al-Attas, Omar S.;Chrousos, George P.
最近发现的肌细胞因子鸢尾素在一些观察性研究中被认为是肥胖相关疾病的潜在治疗靶点。然而，关于这种激素的遗传能力尚无信息。本研究旨在填补这一空白。来自利雅得生物标志物研究项目队列的120个家庭（n = 254； 121名成人和133名儿童）被纳入研究。收集的信息包括人体测量学、血糖、脂质和脂肪细胞因子谱。ELISA法测定鸢尾素含量。检查母亲和后代之间的遗传力，儿子中最显著的遗传性状包括鸢尾素（P = 1.6 x 10(-5)），收缩压（P = 3.6 x 10(-4)），总胆固醇（P = 3.5 x 10(-7)）和LDL（低密度脂蛋白）-胆固醇（P =1.2 x 10(-6)）。母亲和女儿之间的遗传性状再次包括鸢尾素（P < 0.002），以及腰围（P < 0.01）和臀围（P < 0.005）和血压（P < 0.05）等人体测量相关
The recently discovered myokine irisin has been implicated in several observational studies as a potential therapeutic target for obesity-related diseases. However, no information is available as to the heritability of this hormone. The present study aims to fill this gap. A total of 120 families (n = 254; 121 adults and 133 children) were included in the study taken from the Riyadh Biomarkers Research Program cohort. Information gathered include anthropometrics, and glycaemic, lipid and adipocytokine profiles. Irisin was measured using ELISA. Examining heritability between mother and offspring, the most significant heritable traits in sons included irisin (P = 1.6 x 10(-5)), systolic blood pressure (P = 3.6 x 10(-4)), total cholesterol (P = 3.5 x 10(-7)) and LDL (low-density lipoprotein)-cholesterol (P =1.2 x 10(-6)). Heritable traits between mother and daughter again included irisin (P < 0.002), as well as anthropometric associations such as waist (P < 0.01) and hip (P < 0.005) circumference and blood pressure (P