Printed Receive Coils with High Acoustic Transparency for Magnetic Resonance Guided Focused Ultrasound.
Printed Receive Coils with High Acoustic Transparency for Magnetic Resonance Guided Focused Ultrasound.
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DOI：
10.1038/s41598-018-21687-1
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发表时间：
2018-02-21
影响因子：
4.6
通讯作者：
Lustig M
中科院分区：
文献类型：
--
作者：
Corea J;Ye P;Seo D;Butts-Pauly K;Arias AC;Lustig M
在磁共振引导的聚焦超声(MRgFUS)治疗中，声波通过身体聚焦，选择性地消融难以接近的病变和组织。磁共振成像(MRI)扫描仪非侵入性地跟踪整个组织的温度升高，以指导治疗。在临床磁共振成像中，需要由多通道线圈阵列组成的紧密装配的硬件来获取高时空分辨率的高质量图像。消融组织需要一条清晰的声能传播路径，但目前的阵列材料会散射和衰减声能。因此，线圈阵列被放置在换能器外部，远离光束路径，从而影响了扫描的成像速度、分辨率和温度精度。在这里，我们表明，当线圈阵列是通过添加制造(即印刷)制造时，它们具有高达89.5%的声透明度。这使得线圈可以放置在光束路径中，使模体和志愿者的图像信噪比(SNR)提高五倍。我们还表征了印制线圈材料在声学耦合所需的水中随时间变化的特性。这些阵列提供高信噪比和加速能力，可以解决目前头部和腹部肿瘤治疗方面的挑战，使MRgFUS能够为患者提供更好的结果。
In magnetic resonance guided focused ultrasound (MRgFUS) therapy sound waves are focused through the body to selectively ablate difficult to access lesions and tissues. A magnetic resonance imaging (MRI) scanner non-invasively tracks the temperature increase throughout the tissue to guide the therapy. In clinical MRI, tightly fitted hardware comprised of multichannel coil arrays are required to capture high quality images at high spatiotemporal resolution. Ablating tissue requires a clear path for acoustic energy to travel but current array materials scatter and attenuate acoustic energy. As a result coil arrays are placed outside of the transducer, clear of the beam path, compromising imaging speed, resolution, and temperature accuracy of the scan. Here we show that when coil arrays are fabricated by additive manufacturing (i.e., printing), they exhibit acoustic transparency as high as 89.5%. This allows the coils to be placed in the beam path increasing the image signal to noise ratio (SNR) five-fold in phantoms and volunteers. We also characterize printed coil materials properties over time when submerged in the water required for acoustic coupling. These arrays offer high SNR and acceleration capabilities, which can address current challenges in treating head and abdominal tumors allowing MRgFUS to give patients better outcomes.
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影响因子：
158.5
作者：
Elias, W. Jeffrey;Huss, Diane;Wintermark, Max
通讯作者：
Wintermark, Max
影响因子：
3.8
作者：
Payne, A.;Merrill, R.;Parker, D.
通讯作者：
Parker, D.
影响因子：
16.6
作者：
Corea JR;Flynn AM;Lechêne B;Scott G;Reed GD;Shin PJ;Lustig M;Arias AC
通讯作者：
Arias AC
影响因子：
3.1
作者：
Coleman, TF;Li, YY
通讯作者：
Li, YY
影响因子：
3.8
作者：
Pinton, Gianmarco;Aubry, Jean-Francois;Tanter, Mickael
通讯作者：
Tanter, Mickael