The cytokine network in psoriasis.
The cytokine network in psoriasis.
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DOI：
10.1001/archderm.1991.01680050115015
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发表时间：
1991-06
影响因子：
--
通讯作者：
B. Nickoloff
中科院分区：
文献类型：
--
作者：
B. Nickoloff
经过一个多世纪的良性忽视，表皮角质形成细胞终于被认识到其潜在的启动和传播炎症/免疫性皮肤病。在银屑病中，角质形成细胞在活化时积极参与由细胞因子协调的多细胞、多分子网络。表皮角质形成细胞的核心重要性的这种新的欣赏和认识，其独特的免疫生物学能力，除了周围的非上皮细胞类型，已经发生通过使用分子生物学技术和精细的形态学分析，解剖每个隔室（表皮与真皮）到其各自的细胞成分。通过重组具有时空相互关系的基因转录和蛋白质评估，以及细胞因子、趋化肽、生长因子和粘附分子的已知功能特性，可以合成连贯的、生物学上迷人的皮肤马赛克视图。在这篇综述中，探讨了这些新发现对银屑病的影响。当代对银屑病皮肤微环境的分子观点是由运动过度的表皮角质形成细胞的升高和特异性转录活性主导的。的
After more than a century of benign neglect, the epidermal keratinocyte is finally being recognized for its potential to initiate and propagate inflammatory/immunological skin diseases. In psoriasis, the keratinocyte, on activation, actively participates in a multicellular, multimolecular network coordinated by cytokines. This new appreciation and recognition of the central importance of epidermal keratinocytes, with its distinctive immunobiological capabilities apart from surrounding non-epithelial cell types, has occurred by using molecular biological techniques and refined morphological analysis to dissect each compartment (epidermis vs dermis) into their respective cellular constituents. By reassembling gene transcriptional and protein assessments with temporal-spatial interrelationships, and known functional properties of cytokines, chemotactic peptides, growth factors, and adhesion molecules, a coherent, biologically fascinating, mosaic view of the skin can be synthesized. In this review, the ramifications of these new discoveries in psoriasis are explored. The contemporary molecular view of the psoriatic skin microenvironment is dominated by an elevated and specific transcriptional activity on the part of hyperkinetic epidermal keratinocytes. The