Involvement of substance P and the NK-1 receptor in human pathology
Involvement of substance P and the NK-1 receptor in human pathology
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DOI：
10.1007/s00726-014-1736-9
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发表时间：
2014-07-01
期刊：
影响因子：
3.5
通讯作者：
Covenas, Rafael
中科院分区：
文献类型：
--
作者：
Munoz, Miguel;Covenas, Rafael
肽物质P（SP）显示出在中枢和外周神经系统中的广泛分布，但它也存在于不属于神经系统的细胞（免疫细胞、肝、肺、胎盘等）中。SP存在于所有体液中，如血液、脑脊液、母乳等，即它在人体内普遍存在。SP与神经激肽-1（NK-1）受体结合后，调节中枢神经系统中的许多病理生理功能，如情绪行为、应激、抑郁、焦虑、呕吐、偏头痛、酒精成瘾、癫痫发作和神经变性。SP还涉及疼痛、炎症、肝炎、肝毒性、胆汁淤积、瘙痒、心肌炎、细支气管炎、流产、细菌和病毒感染（例如，HIV感染）并且它在癌症中起重要作用（例如，肿瘤细胞增殖、肿瘤细胞中的抗凋亡作用、血管生成、肿瘤细胞的迁移以进行侵袭、浸润和转移）。这意味着SP/NK-1受体系统参与许多人类病理学的分子基础。因此，了解这一系统是更好地理解和更好地管理许多人类疾病的关键。在这篇综述中，我们更新了SP/NK-1受体系统在上述病理生理学中的参与，并提出了未来有价值的治疗干预措施，包括使用NK-1受体拮抗剂，特别是在治疗呕吐，抑郁症，癌症，神经变性，炎症性肠病，病毒感染和瘙痒症，其中该系统上调。
The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also present in cells not belonging to the nervous system (immune cells, liver, lung, placenta, etc.). SP is located in all body fluids, such as blood, cerebrospinal fluid, breast milk, etc. i.e. it is ubiquitous in human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. SP has been also implicated in pain, inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infection (e.g., HIV infection) and it plays an important role in cancer (e.g., tumor cell proliferation, antiapoptotic effects in tumor cells, angiogenesis, migration of tumor cells for invasion, infiltration and metastasis). This means that the SP/NK-1 receptor system is involved in the molecular bases of many human pathologies. Thus, knowledge of this system is the key for a better understanding and hence a better management of many human diseases. In this review, we update the involvement of the SP/NK-1 receptor system in the physiopathology of the above-mentioned pathologies and we suggest valuable future therapeutic interventions involving the use of NK-1 receptor antagonists, particularly in the treatment of emesis, depression, cancer, neural degeneration, inflammatory bowel disease, viral infection and pruritus, in which that system is upregulated.