Targeting polyamine metabolism for cancer therapy and prevention.
Targeting polyamine metabolism for cancer therapy and prevention.
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DOI：
10.1042/bcj20160383
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发表时间：
2016-10-01
期刊：
影响因子：
--
通讯作者：
Casero RA Jr
中科院分区：
文献类型：
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作者：
Murray-Stewart TR;Woster PM;Casero RA Jr
亚精胺和精胺是一种化学性质简单、生物学性质复杂的真核生物多胺，它们是带正电荷的烷基胺，参与许多重要的细胞过程。沿着它们的二胺前体腐胺，它们通常高的细胞内浓度需要通过多种调节机制进行精细衰减，以将这些必需分子保持在严格的生理范围内。由于肿瘤疾病中多胺的代谢和需求经常失调，因此多胺的代谢途径和功能提供了合理的药物靶点;然而，这些靶点难以用于化疗。这篇文章的目的是回顾该领域的最新研究结果，这些研究结果证明了靶向多胺的代谢和功能作为化疗和可能更重要的化学预防策略的潜在效用。
The chemically simple, biologically complex eukaryotic polyamines, spermidine and spermine, are positively charged alkylamines involved in many crucial cellular processes. Along with their diamine precursor putrescine, their normally high intracellular concentrations require fine attenuation by multiple regulatory mechanisms to keep these essential molecules within strict physiologic ranges. Since the metabolism of and requirement for polyamines are frequently dysregulated in neoplastic disease, the metabolic pathway and functions of polyamines provide rational drug targets; however, these targets have been difficult to exploit for chemotherapy. It is the goal of this article to review the latest findings in the field that demonstrate the potential utility of targeting the metabolism and function of polyamines as strategies for both chemotherapy and, possibly more importantly, chemoprevention.