Thiamine destruction by sodium bisulfite in infusion solutions.
Thiamine destruction by sodium bisulfite in infusion solutions.
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输液中的硫胺素被亚硫酸氢钠破坏。
DOI：
10.1093/ajhp/38.12.1911
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
E. DeRitter
中科院分区：
文献类型：
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作者：
J. Scheiner;M. Araújo;E. DeRitter
研究了盐酸硫胺素在亚硫酸氢钠输注液中的降解程度。在500毫升的玻璃或塑料容器中获得含亚硫酸氢钠的两种氨基酸和一种电解质输注溶液，以及不含亚硫酸氢钠的四种输注溶液（5%和10%葡萄糖、乳酸林格注射液和0.9%氯化钠注射液）。三种硫胺素来源，两种商业复合维生素制剂和一种研究复合维生素产品被添加到输液溶液中。通过四个实验测定贮存后添加硫胺素的剩余百分比：(1)将研究产品加入亚硫酸氢盐输注液中，在室温（RT）下光照和黑暗条件下保存24小时；(2)将两种商品复合维生素制剂与含有亚硫酸氢盐的氨基酸溶液混合，在室温下黑暗条件下保存24小时后测定；(3)将研究品加入亚硫酸氢盐输注液中，在7℃下保存2、4、6、8、24小时，在黑暗条件下RT保存4小时后测定；(4)将研究品加入不含亚硫酸氢盐的4种输注液中，在光照和黑暗条件下RT保存24小时后测定。在含有亚硫酸氢盐的输液溶液中，硫胺素的稳定性与pH呈负相关。在pH为6.5的氨基酸溶液中，在室温下保存24小时后，硫胺素的残留量仅为3-8%，在7℃下保存24小时后，硫胺素的残留量仅为37%。在含有亚硫酸氢盐的电解质溶液（pH = 5）中，在室温下保存24小时后，硫胺素的残留量分别为50%和69%。在含有亚硫酸氢盐的溶液中，光暴露不影响硫胺素的稳定性。在不含亚硫酸氢盐的输注溶液中，即使pH范围为4.7-5.6，硫胺素的损失也很小。光暴露对储存在塑料中的溶液的降解作用大于储存在玻璃中的溶液。发现含有亚硫酸氢盐的输液溶液不适用于含有硫胺素的维生素制剂的管理。如果患者必须在亚硫酸氢盐溶液中注射多种维生素，该溶液应在配制后立即使用，并应监测患者是否有硫胺素缺乏的迹象。
The degree of degradation of thiamine hydrochloride in sodium bisulfite-containing infusion solutions was investigated. Two amino acid and one electrolyte infusion solution containing sodium bisulfite and four infusion solutions (5 and 10% dextrose, Lactated Ringer's, and 0.9% sodium chloride injections) without sodium bisulfite were obtained in 500-ml glass or plastic containers. Three thiamine sources, two commercial multivitamin preparations, and one investigational multivitamin product were added to the infusion solutions. The percentage of added thiamine remaining after storage was determined in four experiments: (1) The investigational product was added to the infusion solutions with bisulfite, and the determinations were made after 24 hours of storage at room temperature (RT) under both light and dark conditions; (2) the two commercial multivitamin preparations were mixed with an amino acid solution containing bisulfite and the determination was made after 24 hours of storage at RT under dark conditions; (3) the investigational product was added to the infusion solutions with bisulfite, and the determinations were made after 2, 4, 6, 8, and 24 hours storage at 7 degrees C and following four hours at RT under dark conditions; and (4) the investigational product was added to the four infusion solutions without bisulfite, and the determinations were made after 24 hours of storage at RT under both light and dark conditions. In the infusion solutions containing bisulfite, the stability of thiamine was inversely related to the pH. In an amino acid solution at a pH of 6.5, only 3-8% of the added thiamine was found after 24 hours storage at RT, and only 37% was found after 24 hours at 7 degrees C. In the electrolyte solution with bisulfite (pH = 5), the percentages of thiamine remaining after 24 hours RT and 7 degrees C storage were 50 and 69%, respectively. Light exposure was not found to affect the stability of thiamine in the solutions containing bisulfite. In the infusion solutions without bisulfite, a minimal loss of thiamine occurred even though the pH range was 4.7-5.6. The degradation effect of light exposure was greater for the solutions stored in plastic than in glass. Infusion solutions containing bisulfite were found to be unsuitable vehicles for the administration of vitamin formulations containing thiamine. If a patient must receive multivitamins in infusion solutions with bisulfite, the solutions should be used immediately after their preparation, and the patient should be monitored for signs of thiamine deficiency.