If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung
If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung
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DOI：
10.1111/j.1600-0463.2008.00932.x
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发表时间：
2008-06-01
期刊：
影响因子：
2.8
通讯作者：
Gulmann, Christian
中科院分区：
文献类型：
--
作者：
Downey, Paul;Cummins, Robert;Gulmann, Christian
非小细胞肺癌（NSCLC）的新型靶向治疗需要将NSCLC准确分类为鳞状细胞癌（SCC）和腺癌（AC）。本研究详细描述了组织微阵列中45例NSCLC（24例AC和21例SCC）手术切除的CK 5/6和TTF-1免疫谱。SCC均为CK 5/6阳性，TTF-1阴性。24例腺癌中有20例呈反相。总之，本研究中的所有SCC均为CK 5/6阳性和TTF-1阴性，因此不显示该表型的肿瘤不太可能是SCC。因此，CK 5/6和TTF-1是在常规组织病理学实践中区分肺SCC和AC的实用面板。
Novel targeted treatment of non-small cell lung cancer (NSCLC) requires accurate classification of NSCLC as squamous cell carcinoma (SCC) and adenocarcinoma (AC). This study details the CK5/6 and TTF-1 immunoprofile of surgical resections of 45 NSCLCs (24 ACs and 21 SCCs) in tissue microarrays. All SCCs were CK5/6 positive, TTF-1 negative. 20 of 24 adenocarcinomas had the reverse pattern. In conclusion, all SCCs in this study were CK5/6 positive and TTF-1 negative, and therefore tumours that do not display this phenotype are unlikely to be SCCs. CK5/6 and TTF-1 is therefore a practical panel for the distinction between pulmonary SCC from AC in routine histopathology practice.