Rif1-Dependent Regulation of Genome Replication in Mammals
Rif1-Dependent Regulation of Genome Replication in Mammals
复制标题
DOI：
10.1007/978-981-10-6955-0_12
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Buonomo, Sara B. C.
中科院分区：
文献类型：
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作者：
Buonomo, Sara B. C.
真核生物基因组从多个复制起点开始复制。它们的使用受到严格的调控，并不是所有的潜在起源都在单个细胞周期内被激活。此外，激活的那些是按顺序激活的。为什么复制的起源通常不会一起发生？这很重要吗？如果是，为什么？射击的顺序是否合适，或者具体的顺序是否重要？这个过程是如何调节的？这些问题涉及所有真核生物，但已被证明极难解决，因为复制时间是一个与核功能的多个方面错综复杂地联系在一起的过程。
Eukaryotic genomes are replicated starting from multiple origins of replication. Their usage is tightly regulated, and not all the potential origins are activated during a single cell cycle. In addition, the ones that are activated are activated in a sequential order. Why don't origins of replication normally all fire together? Is this important? And if so, why? Would any order of firing do, or does the specific sequence matter? How is this process regulated? These questions concern all eukaryotes but have proven extremely hard to address because replication timing is a process intricately connected with multiple aspects of nuclear function.