Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries
Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries
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DOI：
10.1038/sj.ijo.0801854
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发表时间：
2002-01-01
影响因子：
4.9
通讯作者：
Wietlisbach, V
中科院分区：
文献类型：
--
作者：
Doll, S;Paccaud, F;Wietlisbach, V
背景：由于发展中国家采用西方高脂肪食物和久坐的生活方式，肥胖症在全球范围内不断增加。与此同时，在许多国家，高血压的上升速度更快，特别是随着年龄的增长，比西方国家。目的：评估肥胖与血压（1313）之间的关系，在一个发展中国家的平均血压高（塞舌尔，印度洋，人口主要为非洲裔）与平均血压较低的发达国家相比设计：基于人群随机抽样的横断面健康检查调查，地点：塞舌尔主岛（马埃岛）和两个瑞士地区（沃-弗里堡和蒂奇诺）受试者：3116名成人（年龄范围35 - 64）未经治疗的高血压。体重指数（BMI）、腰围（WC）、腰臀比（WHIR）、收缩压和舒张压（SBP和DBP，两个测量值的平均值）。方法：散点图平滑技术和性别特异性线性回归模型。平均而言，SBP和DBP在BMI、WHIR和WC的整个变化范围内呈线性增加。在控制年龄的独立回归模型中，发现肥胖和血压水平的每个指标之间存在适度但统计学显著的线性相关。塞舌尔和瑞士两个地区之间的回归系数没有显著差异，但妇女的回归系数普遍高于男子。对于后者，BMI增加1.7 kg/m2，WC增加4.5 cm或WHR增加3.4%对应于SBP升高1 mmHg。妇女的相应数字分别为1.25公斤/平方米、2.5厘米和1.8%。年龄的回归系数反映了更高的影响，这个变量的收缩压和舒张压在塞舌尔比在Switzerland.CONCLUSION：这些研究结果表明一个稳定的线性关系，肥胖与BID，独立的年龄和体脂分布，在发达国家和发展中国家。在后一个国家中观察到的血压随年龄增长更快的增加可能反映了更高的遗传易感性和/或对另一种危险因素的累积暴露高于肥胖。
BACKGROUND: Obesity is increasing worldwide because developing countries are adopting Western high-fat foods and sedentary lifestyles. In parallel, in many of them, hypertension is rising more rapidly, particularly with age, than in Western countries.OBJECTIVE: To assess the relationship between adiposity and blood pressure (1313) in a developing country with high average BP (The Seychelles, Indian Ocean, population mainly of African origin) in comparison to a developed country with low average BP (Switzerland, population mainly of Caucasian origin).DESIGN: Cross-sectional health examination surveys based on population random samples.SETTING: The main Seychelles island (Mahe) and two Swiss regions (Vaud-Fribourg and Ticino).SUBJECTS: Three thousand one hundred and sixteen adults (age range 35 - 64) untreated for hypertension.MEASUREMENTS: Body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHIR), systolic and diastolic blood pressure (SBP and DBP, mean of two measures).METHODS: Scatterplot smoothing techniques and gender-specific linear regression models.RESULTS: On average, SBP and DBP were found to increase linearly over the whole variation range of BMI, WHIR and WC. A modest, but statistically significant linear association was found between each indicator of adiposity and BP levels in separate regression models controlling for age. The regression coefficients were not significantly different between the Seychelles and the two Swiss regions, but were generally higher in women than in men. For the latter, a gain of 1.7 kg/m(2) in BMI, of 4.5 cm in WC or of 3.4% in WHR corresponded to an elevation of 1 mmHg in SBP. For women, corresponding figures were 1.25 kg/m(2), 2.5 cm and 1.8% respectively. Regression coefficients for age reflected a higher effect of this variable on both SBP and DBP in the Seychelles than in Switzerland.CONCLUSION: These findings suggest a stable linear relation of adiposity with BID, independent of age and body fat distribution, across developed and developing countries. The more rapid increase of BP with age observed in the latter countries are likely to reflect higher genetic susceptibility and/or higher cumulative exposure to another risk factor than adiposity.