Activated VEGF Receptor Shed Into the Vitreous in Eyes With Wet AMD A New Class of Biomarkers in the Vitreous With Potential for Predicting the Treatment Timing and Monitoring Response
Activated VEGF Receptor Shed Into the Vitreous in Eyes With Wet AMD A New Class of Biomarkers in the Vitreous With Potential for Predicting the Treatment Timing and Monitoring Response
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DOI：
10.1001/archophthalmol.2009.88
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发表时间：
2009-05-01
影响因子：
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通讯作者：
Glaser, Bert M.
中科院分区：
文献类型：
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作者：
Davuluri, Geetanjali;Espina, Virginia;Glaser, Bert M.
目的：检查磷酸化血管内皮生长因子 (VEGF) 受体流入玻璃体是否反映湿性年龄相关性黄斑变性 (AMD) 中持续的视网膜和脉络膜信号通路活性。 方法：使用反相微阵列对 11 名脉络膜新生血管形成患者注射抗 VEGF 前立即获得的玻璃体样本进行分析。两名患者在注射时和 1 个月后采集了样本。在针对黄斑裂孔、视网膜前膜或视网膜脱离进行玻璃体切除术之前，收集了 5 名患者的样本。结果：玻璃体中存在 VEGF 受体（VEGFR Y996 和 Y1175）、血小板衍生生长因子受体 β（PDGFR β Y716 和 Y751）和 c-KIT (Y703) 的磷酸化形式。 PDGFR beta Y751 存在显着差异（P
Objective: To examine whether phosphorylated vascular endothelial growth factor (VEGF) receptors shed into the vitreous reflect the ongoing retinal and choroidal signal pathway activity in wet age-related macular degeneration (AMD).Methods: Vitreous samples obtained immediately prior to anti-VEGF injection from 11 patients with choroidal neovascularization were analyzed using reverse-phase microarrays. Two patients had samples collected at the time of injection and 1 month later. Samples from 5 patients were collected prior to vitrectomy for macular hole, epiretinal membrane, or retinal detachment.Results: Phosphorylated forms of VEGF receptor (VEGFR Y996 and Y1175), platelet-derived growth factor receptor beta (PDGFR beta Y716 and Y751), and c-KIT (Y703) were present in the Vitreous. A significant difference in PDGFR beta Y751 (P