Fasting insulin concentration is highly correlated with quantitative insulin sensitivity check index
Fasting insulin concentration is highly correlated with quantitative insulin sensitivity check index
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空腹胰岛素浓度与定量胰岛素敏感性检查指标高度相关
DOI：
10.1385/endo:21:2:137
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发表时间：
2003
期刊：
影响因子：
3.7
通讯作者：
J. Vieira
中科院分区：
文献类型：
--
作者：
O. Hauache;J. Vieira
鉴于评价体内胰岛素敏感性的“金标准”方法（高胰岛素-正葡萄糖钳夹技术）由于技术原因不能常规应用，开发了简单的方法和指标，目前可用于评价体内胰岛素敏感性。最近描述了定量胰岛素敏感性检查指数（QUICKI），其能够从空腹血样中准确地估计胰岛素敏感性。我们在三个不同的组中证明了空腹胰岛素水平与QUICKI强烈负相关：215名健康的非糖尿病非肥胖受试者，62名非糖尿病肥胖受试者，44名葡萄糖耐受不良或2型糖尿病患者。空腹胰岛素测量是评估肥胖和非肥胖人群胰岛素敏感性的一种简单方法，无论是否患有葡萄糖耐受不良或2型糖尿病。
Given that the “gold standard” method for evaluating insulin sensitivity in vivo (hyperinsulinemic euglycemic glucose clamp technique) cannot be routinely applied because of technical reasons, simple methods and indexes were developed and are currently available to assess insulin sensitivity in vivo. quantitative insulin sensitivity check index (QUICKI) has recently been described and is able to accurately estimate insulin sensitivity from a fasting blood sample. We demonstrated that fasting insulin levels strongly inversely correlated with QUICKI in three different groups: 215 healthy nondiabetic nonobese subjects, 62 nondiabetic obese subjects, and 44 patients with glucose intolerance or type 2 diabetes mellitus. Fasting insulin measurement is a simple way of assessing insulin sensitivity in obese and nonobese humans, with or without glucose intolerance or type 2 diabetes mellitus.