Inflammation, Immune Activation, and Antiretroviral Therapy in HIV.
Inflammation, Immune Activation, and Antiretroviral Therapy in HIV.
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DOI：
10.1007/s11904-017-0356-x
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发表时间：
2017-06
影响因子：
4.6
通讯作者：
Funderburg NT
中科院分区：
文献类型：
--
作者：
Hileman CO;Funderburg NT
这篇综述着重于当代抗逆转录病毒药物对全身炎症的不同影响，因为免疫激活与HIV感染的重要共病和死亡率有关。抗逆转录病毒疗法(ART)显著减少全身炎症和免疫激活，但不能达到与未感染艾滋病毒的人群同步的水平。在一项ART启动试验中，整合酶抑制剂似乎比非核苷逆转录酶抑制剂(NNRTI)更能减轻炎症；然而，在ART幼稚患者中，与PI、PI和NNRTI之间、特定核苷逆转录酶抑制剂之间或马拉韦罗相比，整合酶抑制剂治疗炎症是否有好处尚不清楚。在ART SWITCH研究中，从PI-、NNRTI-或Enfuvitide-方案改为整合酶抑制剂可导致几个炎症标志物的改善。还需要进一步的研究来得出结论，特定的抗逆转录病毒药物对艾滋病毒的炎症和免疫激活的影响是否存在明显的差异。
This review focuses on the differential effects of contemporary antiretrovirals on systemic inflammation as heightened immune activation is linked to important co-morbidities and mortality with HIV infection. Antiretroviral therapy (ART) reduces dramatically systemic inflammation and immune activation, but not to levels synchronous with HIV-uninfected populations. In one ART initiation trial, integrase inhibitors appear to reduce inflammation to a greater degree than non-nucleoside reverse transcriptase inhibitors (NNRTIs); however, it is not clear that there are beneficial effects on inflammation resulting from treatment with integrase inhibitors compared to PIs, between PIs and NNRTIs, between specific nucleoside reverse transcriptase inhibitors, or with maraviroc in ART-naïve patients. In ART switch studies, changing to an integrase inhibitor from a PI-, NNRTI-, or enfuvirtide-containing regimen has resulted in improvement in several markers of inflammation. Additional research is needed to conclusively state whether there are clear differences in effects of specific antiretrovirals on inflammation and immune activation in HIV.
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DOI：
10.1097/qai.0000000000000478
发表时间：
2015-04-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Funderburg NT;Jiang Y;Debanne SM;Labbato D;Juchnowski S;Ferrari B;Clagett B;Robinson J;Lederman MM;McComsey GA
通讯作者：
McComsey GA
影响因子：
6
作者：
Crowell, Trevor A.;Fletcher, James L. K.;Ananworanich, Jintanat
通讯作者：
Ananworanich, Jintanat
影响因子：
39
作者：
Freiberg MS;Chang CC;Kuller LH;Skanderson M;Lowy E;Kraemer KL;Butt AA;Bidwell Goetz M;Leaf D;Oursler KA;Rimland D;Rodriguez Barradas M;Brown S;Gibert C;McGinnis K;Crothers K;Sico J;Crane H;Warner A;Gottlieb S;Gottdiener J;Tracy RP;Budoff M;Watson C;Armah KA;Doebler D;Bryant K;Justice AC
通讯作者：
Justice AC
DOI：
10.4049/jimmunol.1001801
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gordon SN;Cervasi B;Odorizzi P;Silverman R;Aberra F;Ginsberg G;Estes JD;Paiardini M;Frank I;Silvestri G
通讯作者：
Silvestri G
影响因子：
56.3
作者：
Arribas, Jose R.;Pialoux, Gilles;Piontkowsky, David
通讯作者：
Piontkowsky, David