Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy
Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy
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DOI：
10.1088/0957-4484/26/11/115102
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发表时间：
2015-03-20
期刊：
影响因子：
3.5
通讯作者：
Liu, Jingfeng
中科院分区：
文献类型：
--
作者：
Wu, Ming;Zhang, Da;Liu, Jingfeng
在本文中，核-壳纳米复合材料的簇的超顺磁性氧化铁纳米粒子涂有聚（多巴胺）（SPION集群@PDA）制造作为磁场导向的治疗诊断剂，结合了高灵敏度的磁共振成像（MRI）和光热癌症治疗的能力。高浓度的SPION簇核由于其超顺磁性而适合于灵敏的MRI，并且聚（多巴胺）涂层由于PDA的光热转换能力而可以在近红外（NIR）激光照射下诱导癌细胞死亡。MRI扫描显示，纳米复合材料具有相对高的r（2）和r（2）* 弛豫率，并且r（2）* 值几乎是r2值的三倍，这是因为SPION在纳米复合材料芯中的聚集。由于对磁场梯度的快速响应，可以实现由外部磁场介导的我们的纳米复合材料的增强的细胞摄取，从而在NIR刺激下产生显著增强的针对癌细胞的局部光热杀伤效率。
In this paper, a core-shell nanocomposite of clusters of superparamagnetic iron oxide nanoparticles coated with poly(dopamine) (SPION clusters@PDA) is fabricated as a magnetic field-directed theranostic agent that combines the capabilities of highly sensitive magnetic resonance imaging (MRI) and photothermal cancer therapy. The highly concentrated SPION cluster core is suitable for sensitive MRI due to its superparamagnetic properties, and the poly (dopamine) coating layer can induce cancer cell death under near-infrared (NIR) laser irradiation because of the photothermal conversion ability of PDA. MRI scanning reveals that the nanocomposite has relatively high r(2) and r(2)* relaxivities, and the r(2)* values are nearly threefold higher than the r2 values because of the clustering of the SPIONs in the nanocomposite core. Due to the rapid response to magnetic field gradients, enhanced cellular uptake of our nanocomposite mediated by an external magnetic field can be achieved, thus producing significantly enhanced local photothermal killing efficiency against cancer cells under NIR irritation.