Role of serotonin2C receptors in the control of brain dopaminergic function
Role of serotonin2C receptors in the control of brain dopaminergic function
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DOI：
10.1016/s0091-3057(01)00705-5
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发表时间：
2002-04-01
影响因子：
3.6
通讯作者：
Esposito, E
中科院分区：
文献类型：
--
作者：
Di Matteo, V;Cacchio, M;Esposito, E
有大量证据表明，起源于腹侧被盖区（VTA）的中皮质边缘多巴胺（DA）系统的功能状态是在多巴胺能系统的相位和紧张性抑制控制下，该系统通过刺激5-羟色胺（2C）（5-HT 2C）受体亚型发挥作用。这一论断是基于大量的电生理和生物化学数据，显示5-HT 2C受体激动剂降低，而5-HT 2C受体拮抗剂增强中皮质边缘DA功能。另一方面，5-HT 2C受体在黑质黑质纹状体DA系统的调控中似乎不起作用。本文作者回顾了关于5-HT 2C受体在控制脑DA功能中作用的最相关数据，并强调了这一主题在寻找神经精神疾病（如抑郁症、精神分裂症、药物成瘾和帕金森病）新疗法中的重要性。(C)2002年爱思唯尔科技有限公司All rights reserved.
There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin(2C) (5-HT2C) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT2C receptor agonists decrease, while 5-HT2C receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT2C receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT2C receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease. (C) 2002 Elsevier Science Inc. All rights reserved.