The gastrointestinal microbiota and its role in oncogenesis
The gastrointestinal microbiota and its role in oncogenesis
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DOI：
10.1016/j.bpg.2017.09.010
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发表时间：
2017-12-01
影响因子：
3.2
通讯作者：
Fuhler, G. M.
中科院分区：
文献类型：
--
作者：
Lam, S. Y.;Yu, J.;Fuhler, G. M.
研究技术的进步使人们有可能绘制胃肠道（GI）中的微生物群落，人体中大多数细菌都居住在那里。这些社区中的干扰被称为生态失调，并与GI癌症有关。虽然在几种胃肠道恶性肿瘤中观察到生态失调，但这些变化的具体作用尚未被理解到幽门螺杆菌（HP）在胃癌（GC）中的程度。这篇综述将讨论从口腔到肛管的胃肠道沿着的细菌群落，特别关注细菌的生态失调和致癌作用。正如胃中的非HP细菌可能在胃癌发生中与HP相互作用一样，这同样适用于其他胃肠道恶性肿瘤，其中微生物之间的相互作用似乎是可以想象的，特别是在结直肠癌（CRC）中。在本文的最后部分，我们将讨论细菌生态失调在胃肠道癌变中的潜在机制。(C)2017爱思唯尔有限公司版权所有
Advances in research techniques have made it possible to map the microbial communities in the gastrointestinal (GI) tract, where the majority of bacteria in the human body reside. Disturbances in these communities are referred to as dysbiosis and have been associated with GI cancers. Although dysbiosis is observed in several GI malignancies, the specific role of these changes has not been understood to the extent of Helicobacter pylori (HP) in gastric cancer (GC). This review will address the bacterial communities along the GI tract, from the oral cavity to the anal canal, particularly focusing on bacterial dysbiosis and carcinogenesis. Just as non-HP bacteria in the stomach may interact with HP in gastric carcinogenesis, the same may hold true for other GI tract malignancies, where an interplay between microbes in carcinogenesis seems conceivable, especially in colorectal cancer (CRC). In the last part of this review we will discuss the potential mechanisms of bacterial dysbiosis in GI carcinogenesis. (C) 2017 Elsevier Ltd. All rights reserved.