The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine induced place preference conditioning in mice
The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine induced place preference conditioning in mice
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DOI：
10.1007/bf02247330
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发表时间：
1996-06-01
影响因子：
3.4
通讯作者：
Baeyens, JM
中科院分区：
文献类型：
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作者：
DelPozo, E;Barrios, M;Baeyens, JM
研究了非竞争性NMDA受体拮抗剂地佐环平（MK-801）对吗啡诱导的小鼠条件性位置偏爱的影响。正如预期的那样，吗啡（1-8 mg/kg，IP）引起对药物配对隔室的显著偏好。预处理小鼠（+）-地佐环平（0.1和0.2 mg/kg，IP），更积极的地佐环平对映体，剂量依赖性逆转吗啡（4 mg/kg，IP）产生的条件性位置偏爱，而（-）-地佐环平（0.2 mg/kg，IP）没有修改吗啡诱导的效果。相反，地佐环平的两种对映体（剂量为0.2 mg/kg，IP）引起条件性位置偏爱。这些数据表明：（1）NMDA受体在吗啡诱导的位置偏爱中发挥作用，（2）地佐环平在位置偏爱范式中的强化特性似乎不依赖于NMDA受体阻断。
The effect of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) on conditioned place preference induced by morphine was studied in mice. As expected, morphine (1-8 mg/kg, IP) elicited a significant preference for the drug-paired compartment. Pretreatment of mice with (+)-dizocilpine (0.1 and 0.2 mg/kg, IP), the more active dizocilpine enantiomer, dose-dependently reversed the conditioned place preference produced by morphine (4 mg/kg, IP), whereas (-)-dizocilpine (0.2 mg/kg, IP) did not modify morphine-induced effects. In contrast, both enantiomers of dizocilpine (at a dose of 0.2 mg/kg, IP) elicited a conditioned place preference. These data suggest that (1) NMDA receptors play a role in morphine-induced place preference, and (2) dizocilpine-reinforcing properties in the place preference paradigm do not seem to be dependent on NMDA receptor blockade.