Polyphenol-Inspired Facile Construction of Smart Assemblies for ATP- and pH-Responsive Tumor MR/Optical Imaging and Photothermal Therapy
Polyphenol-Inspired Facile Construction of Smart Assemblies for ATP- and pH-Responsive Tumor MR/Optical Imaging and Photothermal Therapy
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受多酚启发，轻松构建用于 ATP 和 pH 响应肿瘤 MR/光学成像和光热治疗的智能组件
DOI：
10.1002/smll.201603997
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发表时间：
2017-05-24
期刊：
影响因子：
13.3
通讯作者：
Yang, Huang-Hao
中科院分区：
文献类型：
--
作者：
Song, Xiao-Rong;Li, Shi-Hua;Yang, Huang-Hao
智能组件在各个领域引起了越来越多的兴趣，特别是在开发新型刺激响应治疗诊断学方面。本文中，市售的天然单宁酸（TA）和氧化铁纳米颗粒（Fe 3 O 4 NPs）被用作模型以基于NPs和TA之间的受多酚启发的NPs-酚自组装来构建智能磁性组件。有趣的是，磁性组装体可以被腺苷三磷酸特异性地分解，腺苷三磷酸显示出比TA更强的对Fe 3 O 4 NPs的亲和力，并部分取代表面配位的TA。酸性环境可以进一步促进分解，从而导致横向弛豫率的显着变化和荧光（FL）信号的有效“开启”。因此，成功地使用了用于特异性和灵敏的肿瘤磁共振和FL双模成像以及静脉注射后的光热治疗的组件。这项工作不仅提供了对纳米粒子和多酚之间的自组装的理解，而且将开辟新的见解，方便地构建多功能组件和扩展其生物医学应用。
Smart assemblies have attracted increased interest in various areas, especially in developing novel stimuli-responsive theranostics. Herein, commercially available, natural tannic acid (TA) and iron oxide nanoparticles (Fe3O4 NPs) are utilized as models to construct smart magnetic assemblies based on polyphenol-inspired NPs-phenolic self-assembly between NPs and TA. Interestingly, the magnetic assemblies can be specially disassembled by adenosine triphosphate, which shows a stronger affinity to Fe3O4 NPs than that of TA and partly replaces the surface coordinated TA. The disassembly can further be facilitated by the acidic environment hence causing the remarkable change of the transverse relaxivity and potent "turn-on" of fluorescence (FL) signals. Therefore, the assemblies for specific and sensitive tumor magnetic resonance and FL dual-modal imaging and photothermal therapy after intravenous injection of the assemblies are successfully employed. This work not only provides understandings on the self-assembly between NPs and polyphenols, but also will open new insights for facilely constructing versatile assemblies and extending their biomedical applications.