Cytotoxic prenylflavanones from Taiwanese propolis
Cytotoxic prenylflavanones from Taiwanese propolis
复制标题
DOI：
10.1021/np0203180
复制
发表时间：
2003-04-01
影响因子：
5.1
通讯作者：
Lin, JK
中科院分区：
文献类型：
--
作者：
Chen, CN;Wu, CL;Lin, JK
从台湾蜂胶中分离到两个新的丙烯基黄烷酮，分别为蜂胶蛋白A(2)和蜂胶蛋白B(3)。这两种化合物都被发现对三种癌细胞系具有细胞毒性。DNA含量分析和DNA片段分析表明，propolin A(2)能有效诱导癌细胞凋亡，但对细胞周期程序无影响。此外，丙胶A(2)和B(3)都是潜在的抗氧化剂，对大多数类型的自由基都有很强的清除作用。
Two new prenylflavanones, propolin A (2) and propolin B (3), were isolated and characterized from Taiwanese propolis. Both compounds were found to have cytotoxic properties against three cancer cell lines. DNA content analyses and DNA fragmentation indicated that propolin A (2) efficiently induced apoptosis in cancer cell lines, but had no effect on the cell cycle program. Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals.