Novel lipoxygenase inhibitors, tetrapetalone B, C, and D from Streptomyces sp.
Novel lipoxygenase inhibitors, tetrapetalone B, C, and D from Streptomyces sp.
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DOI：
10.1271/bbb.68.903
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发表时间：
2004-04-01
影响因子：
1.6
通讯作者：
Hirota, A
中科院分区：
文献类型：
--
作者：
Komoda, T;Kishi, M;Hirota, A
从同时产生脂氧合酶抑制剂tetrapetalone A（1）的链霉菌USF-4727的发酵液中分离得到三个新的脂氧合酶抑制剂tetrapetalone B（2，C28 H35 NO 9），C（3，C26 H34 NO 8），D（4，C28 H36 NO10）。通过光谱学证据揭示了每种化合物的化学结构，这表明这三种化合物在结构上与1。它们具有四环骨架和β-D-玫瑰糖基部分。替诺他隆B、C和D抑制大豆脂肪氧合酶，IC 50分别为320、360和340 μ m。
Three novel lipoxygenase inhibitors, tetrapetalone B (2, C28H35NO9), C (3, C26H34NO8), and D (4, C28H36NO10), were isolated from a culture broth of Streptomyces sp. USF-4727 that produced a lipoxygenase inhibitor tetrapetalone A (1) simultaneously. Each chemical structure was revealed by spectroscopic evidence, this suggests that these three compounds are structurally related to 1. They had a tetracyclic skeleton and a beta-D-rhodinosyl moiety. Tetrapetalone B, C, and D inhibited soybean lipoxygenase with IC50: 320, 360, and 340 mum respectively.