Splenectomy Does Not Improve Long-Term Outcome After Stroke.
Splenectomy Does Not Improve Long-Term Outcome After Stroke.
复制标题
脾切除术不能改善中风后的长期预后。
DOI：
10.1161/strokeaha.116.016037
复制
发表时间：
2017
期刊：
影响因子：
8.3
通讯作者：
Becker,KyraJ
中科院分区：
文献类型：
--
作者：
Zierath,Dannielle;Shen,Angela;Stults,Astiana;Olmstead,Theresa;Becker,KyraJ
Background and PurposeImmune responses to brain antigens after stroke contribute to poor outcome. We hypothesized that splenectomy would lessen the development of such responses and improve outcome.MethodsMale Lewis rats (275–350 g) underwent 2-hour middle cerebral artery occlusion immediately after splenectomy or sham splenectomy. Animals were survived to 4 weeks (672 hrs), and immune responses to myelin basic protein determined at euthanasia. Infarct volume was determined in a subset of animals euthanized at 72 hours. Behavioral outcomes were assessed to 672 hours.ResultsSplenectomy was associated with worse neurological scores early after stroke, but infarct size at 72 hours was similar in both groups. Behavioral outcomes and immune responses to myelin basic protein were also similar among splenectomized and sham-operated animals 672 hours after middle cerebral artery occlusion.ConclusionsSplenectomy did not alter the immune responses to brain antigens or improve outcome after stroke. Differences between this study and other studies of splenectomy and stroke are examined.
