INFANT BIRTH-WEIGHT IS RELATED TO MATERNAL ARTERIAL OXYGENATION AT HIGH-ALTITUDE
INFANT BIRTH-WEIGHT IS RELATED TO MATERNAL ARTERIAL OXYGENATION AT HIGH-ALTITUDE
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DOI：
10.1152/jappl.1982.52.3.695
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发表时间：
1982-01-01
影响因子：
3.3
通讯作者：
REEVES, JT
中科院分区：
文献类型：
--
作者：
MOORE, LG;ROUNDS, SS;REEVES, JT
据报道，由于胎儿生长迟缓，高海拔地区的婴儿出生体重会下降，但并不是所有在高海拔地区出生的婴儿都很小。母亲的特征与较低的动脉氧气含量有关，这可能有助于婴儿出生时体重较小。为了验证这一假设，对美国科罗拉多州莱德维尔(海拔3100米)的44名居民在孕期和产后连续测量了动脉血氧分压。测量了与子代出生体重相关的三个母体特征(通风、Hb浓度和吸烟习惯)。较小婴儿的母亲(2900克)与较大婴儿的母亲(3500克)相比，特征是呼吸不足，从妊娠早期到晚期，呼吸和动脉血氧饱和度没有变化或减少，以及Hb浓度下降，导致妊娠晚期动脉血氧含量降低。母亲在海拔3100米吸烟与婴儿出生体重(-546克)的下降幅度是报道的海平面水平的2到3倍。孕期母体动脉血氧分压可能是预测胎儿生长迟缓和高原适应过程的重要指标。
Infant birth weight is reported to decrease at high altitude as a result of fetal growth retardation, but not all babies born at high altitude are small. Maternal characteristics acting to lower arterial O2 content may contribute to smaller infant birth weight. To test this hypothesis, arterial oxygenation was measured serially during pregnancy and again postpartum in 44 residents of Leadville, Colorado [USA] (elevation 3100 m). Three maternal characteristics (ventilation, Hb concentration and smoking habits) related to the birth weight of the offspring were measured. Mothers of smaller babies (< 2900 g), compared to mothers of larger babies (> 3500 g), were characterized by hypoventilation, no change or a decrease in ventilation and arterial O2 saturation from early to late gestation, and a falling Hb concentration that combined to lower arterial O2 content in the 3rd trimester. Maternal smoking at 3100 m was associated with a 2- to 3-fold greater reduction in infant birth weight (-546 g) than reported from sea level. Maternal arterial oxygenation during pregnancy may be important for predicting fetal growth retardation and the process of adaptation to high altitude.