Difluorocarbene for Dehydroxytrifluoromethylthiolation of Alcohols
Difluorocarbene for Dehydroxytrifluoromethylthiolation of Alcohols
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二氟卡宾用于醇的脱羟基三氟甲硫基化
DOI：
10.1021/acs.joc.7b01701
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发表时间：
2017
影响因子：
3.6
通讯作者：
Xiao Ji-Chang
中科院分区：
文献类型：
--
作者：
Luo Jia-Jia;Zhang Min;Lin Jin-Hong;Xiao Ji-Chang
描述了用Ph_3P + CF_2CO_2-/S_8/F-体系进行的醇的脱羟基三氟甲基硫醇化反应。由Ph 3 P + CF2 CO2-生成的二氟卡宾很容易与元素硫联合收割机结合生成S = CF2。S-CF2可以被认为是一种双功能中间体，活化醇并为CF 3S-形成提供支架，从而允许醇的方便脱羟基三氟甲基硫醇化。
Dehydroxytrifluoromethylthiolation of alcohols with a Ph3P+CF2CO2–/S8/F–system is described. Difluorocarbene generated from Ph3P+CF2CO2–would readily combine with elemental sulfur to furnish SCF2. SCF2can be considered as a bifunctional intermediate, activating alcohol and providing scaffold for CF3S–formation, thus allowing for the convenient dehydroxytrifluoromethylthiolation of alcohols.