Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis
Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis
复制标题
肽功能化靶向脂质体：用于针对血管生成的纳米级药物递送
DOI：
10.1039/c6tb01823h
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发表时间：
2016-01-01
影响因子：
7
通讯作者：
Hu, Zhiyuan
中科院分区：
文献类型：
--
作者：
Han, Qiuju;Jia, Xiangqian;Hu, Zhiyuan
采用“一珠一化合物”（OBOC）的方法，在微阵列芯片上筛选出一种新的亲和肽S1（LIDHEWKENYFPLSF）。研究发现，S1能特异性识别并结合血管内皮生长因子受体2（VEGFR 2），这是一种血管生成生物标志物。此外，S1功能化脂质体（S1-LS）可以实现有效的纳米级药物递送的VEGFR 2-过表达的条件下，在体外和体内。结果表明，S1-LS是一种很有前途的VEGFR 2靶向给药系统。
A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound'' (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.