TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation
TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation
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DOI：
10.1074/jbc.m111.310599
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发表时间：
2011-12-16
影响因子：
4.8
通讯作者：
Kanneganti, Thirumala-Devi
中科院分区：
文献类型：
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作者：
Anand, Paras K.;Tait, Stephen W. G.;Kanneganti, Thirumala-Devi
背景：单核细胞增多性李斯特菌是一种侵入宿主细胞质的细胞内病原体。结果：TLR2和NOD2基因缺陷的细胞显示出李斯特菌的自噬缺陷。结论：李斯特菌的自噬依赖于ERK途径，而ERK信号通路在TLR2和NOD2基因缺陷的细胞中被干扰。意义：我们的研究确立了先天免疫受体在细胞内病原体自噬中的作用。
Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm.Results: Cells deficient in TLR2 and NOD2 show defective autophagy of Listeria monocytogenes.Conclusion: Autophagy of Listeria is dependent on ERK pathway that is perturbed in TLR2- and NOD2-deficient cells.Significance: Our study establishes the role of innate immune receptors in autophagy of intracellular pathogens.