MBL2 Gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype
MBL2 Gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype
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DOI：
10.1016/j.humimm.2008.01.005
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发表时间：
2008-02-01
期刊：
影响因子：
2.7
通讯作者：
Crovella, Sergio
中科院分区：
文献类型：
--
作者：
Acioli-Santos, Bartolomeu;Segat, Ludovica;Crovella, Sergio
登革热在临床上可以从一种无症状的轻度疾病（称为登革热）演变为一种严重的疾病，称为登革出血热（DHF）。最近的证据表明，宿主遗传因素如何与严重登革热易感性或保护相关。这些基因中的许多基因，如CD 209、TNF-α、维生素D受体和FC γ受体IIA，是先天免疫系统的组成部分，这表明先天反应可能在登革热发病机制中起作用。MBL 2基因多态性已被证明在许多病毒性疾病中调节易感性或保护作用。我们通过分析已知与MBL蛋白血清水平降低相关的MBL 2外显子1多态性（密码子52、54和57），研究了MBL 2基因在登革热临床结局中的参与。对110例特征明确的登革热阳性患者的基因型进行统计分析，以确定MBL 2多态性与性别、感染类型（主要或次要应答）、种族/民族、感染病程和年龄等参数之间可能的相关性。我们发现野生型AA MBL 2基因型和年龄之间存在显著相关性，是登革热相关性血小板减少症发生的相关危险因素。(C)2008年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
Dengue disease can clinically evolve from an asymptomatic and mild disease, known as dengue fever IN), to a severe disease known as dengue hemorrhagic fever (DHF). Recent evidence has shown how host genetic factors can be correlated with severe dengue susceptibility or protection. Many of these genes, such as CD209, TNF-a, vitamin D receptor, and FC gamma receptor IIA, are components of the innate immune system, suggesting that innate responses might have a rote in dengue pathogenesis. MBL2 gene polymorphisms have been shown to modulate susceptibility or protection in many viral diseases. We investigated the involvement of MBL2 gene in the dengue clinical outcome through the analysis of MBL2 exon 1 polymorphisms (at codons 52, 54, and 57) known to be associated with reduced serum levels of the MBL protein. The genotypes of 110 well-characterized dengue-positive patients were statistically analyzed to establish possible correlations between MBL2 polymorphisms and parameters such as sex, type of infection (primary or secondary response), race/ethnicity, course of infection, and age. We found significant correlations between wild-type AA MBL2 genotype and age as associated risk factors for development of dengue-related thrombocytopenia. (C) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.