Cancer incidence attributable to alcohol consumption in Alberta in 2012.
Cancer incidence attributable to alcohol consumption in Alberta in 2012.
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DOI：
10.9778/cmajo.20160070
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发表时间：
2016-07-01
期刊：
影响因子：
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通讯作者：
Brenner, Darren R
中科院分区：
文献类型：
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作者：
Grundy, Anne;Poirier, Abbey E;Brenner, Darren R
背景：饮酒与口腔/咽癌、喉癌、食道癌、肝癌、结直肠癌和乳腺癌的风险相关。本研究的目的是估计2012年阿尔伯塔省可归因于饮酒的这些癌症的比例和总数。方法：我们使用人口归因风险计算来估计阿尔伯塔省成年人因饮酒导致的癌症。从最近的荟萃分析中获得了相对风险，并使用加拿大社区健康调查的数据对艾伯塔省的酒精消费量进行了量化。我们从艾伯塔省癌症登记处获得了2012年年龄、部位和性别特异性癌症发病率数据。使用加拿大统计局的人均酒精销售数据，评估了加拿大社区健康调查数据中潜在低估酒精消费的影响。结果：在艾伯塔省，男性因饮酒导致的癌症比例低至5.1%（肝脏），高至19.9%（口腔/咽部），女性因饮酒导致的癌症比例低至2.1%（肝脏），高至7.6%（口腔/咽部）。普通癌症（结直肠癌、女性乳腺癌）的酒精归因癌症病例总数最高，而在个别癌症部位，上呼吸道癌症的人群归因风险最高。在艾伯塔省，与酒精有关的癌症中有4.8%（占所有癌症的1.6%）可归因于饮酒。在对饮酒记录进行调整后，我们对人群归因风险的估计增加到10.7%的酒精相关癌症和3.5%的所有癌症。解释：据估计，酒精消费占艾伯塔省癌症病例总数的1.6%-3.5%。鉴于就癌症风险而言，任何程度的酒精消费都不被认为是安全的，减少酒精消费的战略有可能减轻艾伯塔省的癌症负担。
BACKGROUND: Alcohol consumption has been associated with risk of oral cavity/pharyngeal, laryngeal, esophageal, liver, colorectal and breast cancers. The purpose of this study was to estimate the proportion and total number of these cancers in Alberta in 2012 attributable to alcohol consumption.METHODS: We estimated cancers attributable to alcohol consumption in adults in Alberta using population attributable risk calculations. Relative risks were obtained from recent meta-analyses, and alcohol consumption in Alberta was quantified with the use of data from the Canadian Community Health Survey. We obtained age-, site- and sex-specific cancer incidence data for 2012 from the Alberta Cancer Registry. The impact of potential underestimation of alcohol consumption in Canadian Community Health Survey data was evaluated with the use of per-capita alcohol sales data from Statistics Canada.RESULTS: Proportions of cancers attributable to alcohol consumption at individual cancer sites were estimated to be as low as 5.1% (liver) and as high as 19.9% (oral cavity/pharynx) among men and as low as 2.1% (liver) and as high as 7.6% (oral cavity/pharynx) among women in Alberta. The total number of alcohol-attributable cancer cases was highest for common cancers (colorectal, female breast), whereas at individual cancer sites, population attributable risks were highest for upper aerodigestive tract cancers. A total of 4.8% of alcohol-associated cancers (1.6% of all cancers) in Alberta could be attributed to alcohol consumption. After adjustment for recorded alcohol consumption, our estimates of population attributable risk increased to 10.7% of alcohol-associated cancers and 3.5% of all cancers.INTERPRETATION: Alcohol consumption is estimated to account for 1.6%-3.5% of total cancer cases in Alberta. Given that no level of alcohol consumption is considered safe with respect to cancer risk, strategies to reduce alcohol consumption have the potential to reduce Alberta's cancer burden.