Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion
Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion
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DOI：
10.1007/s00417-007-0610-9
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发表时间：
2007-12-01
影响因子：
2.7
通讯作者：
Miyake, Yozo
中科院分区：
文献类型：
--
作者：
Inomata, Koichi;Shinoda, Kei;Miyake, Yozo
目的报道经角膜电刺激(TES)治疗陈旧性视网膜动脉阻塞(RAO)的疗效。设计开放标签，病例系列。患者与方法2例中央型RAO患者(分别15个月和33个月)和1例分支RAO患者(26个月)接受TES治疗。术前、术后分别进行主客观眼科检查。患者年龄分别为38岁、49岁和63岁。TES(20赫兹双相脉冲，30min，最大1100UA)由双极接触镜电极每月1次，连续3个月。结果2例患者视力提高0.2logMAR单位以上，3例患者视野均有改善。2例患者治疗后视网膜缺血区对应部位的多焦ERG均有所改善。除一过性浅表性角膜炎外，无眼部和全身不良反应。结论视网膜切除术可改善长期存在的RAOS患者的视网膜功能。
Purpose To report the outcome of transcorneal electrical stimulation (TES) of the visual system on long-standing retinal artery occlusion (RAO).Design Open labeled, case series.Patients and methods Two patients with central RAO (15 and 33 months respectively) and one with branch RAO (26 months) underwent TES therapy. Subjective and objective ophthalmological evaluations were performed before and after the TES. The ages of the patients were 38, 49, and 63 years. The TES (20 Hz biphasic pulses, 30 minutes, up to 1100 uA) was delivered by a bipolar contact lens electrode once a month for 3 months. Perimetric and/or electrophysiological examinations were performed as outcome measures.Results The visual acuity improved by more than 0.2 logMAR units in two cases, and the visual fields were improved in all three cases. The multifocal ERGs which had been reduced in the loci corresponding to the ischemic retinal area were improved after the treatment in two cases. Neither ocular nor systemic adverse effects were observed except for transient superficial keratitis.Conclusions TES of the retina can improve retinal function in eyes with long-standing RAOs.