Correlates of virtual navigation performance in older adults.
Correlates of virtual navigation performance in older adults.
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DOI：
10.1016/j.neurobiolaging.2015.12.003
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发表时间：
2016-03
影响因子：
4.2
通讯作者：
Driscoll I
中科院分区：
文献类型：
--
作者：
Korthauer LE;Nowak NT;Moffat SD;An Y;Rowland LM;Barker PB;Resnick SM;Driscoll I
尽管有相当多的证据表明，老化对位置学习和记忆的有害影响，但对这些递减的轨迹和假定的神经机制知之甚少。虚拟莫里斯水任务（vMWT）是非人类空间导航任务的人类模拟。本研究调查了51名健康非痴呆成年人（年龄30-83岁）在两个时间点（间隔= ~8年）完成vMWT和神经心理电池的位置学习的纵向变化。我们还评估了vMWT与脑结构，生化完整性和标准化神经心理学指标之间的横断面相关性，这些指标在随访时接受了MR成像的22名个体中进行了评估。尽管vMWT性能没有纵向下降，但vMWT存在有利于年轻成人的横截面年龄差异。观察到vMWT潜伏期与右侧海马、双侧丘脑和右侧内侧眶额皮质的灰质体积之间以及vMWT潜伏期与双侧钩束的白色物质分数各向异性之间存在负相关。总的来说，这些结果表明，即使在没有纵向性能下降的情况下，支持成功导航的区域的结构完整性的差异模式。
Despite considerable evidence for deleterious effects of aging on place learning and memory, less is known about the trajectory and the putative neural mechanisms of these decrements. The virtual Morris Water Task (vMWT) is a human analog of a non-human spatial navigation task. The present study investigated longitudinal changes in place learning in 51 healthy, non-demented adults (age 30–83) who completed the vMWT and a neuropsychological battery at two time-points (interval= ~8 years). We also assessed cross-sectional associations between vMWT and brain structure, biochemical integrity, and standardized neuropsychological measures in a subset of 22 individuals who underwent MR imaging at follow-up. Despite no longitudinal decrement in vMWT performance, there were cross-sectional age differences on the vMWT favoring younger adults. Negative associations were observed between vMWT latency and gray matter volumes in the right hippocampus, bilateral thalamus, and right medial orbitofrontal cortex, and between vMWT latency and white matter fractional anisotropy in the bilateral uncinate fasciculus. Collectively, these results suggest a pattern of differences in the structural integrity of regions supporting successful navigation even in the absence of longitudinal performance decrements.