DETERMINATION OF HEPATIC ARTERIAL BLOOD FLOW AND OXYGEN SUPPLY IN MAN BY CLAMPING HEPATIC ARTERY DURING SURGERY
DETERMINATION OF HEPATIC ARTERIAL BLOOD FLOW AND OXYGEN SUPPLY IN MAN BY CLAMPING HEPATIC ARTERY DURING SURGERY
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DOI：
10.1172/jci104497
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发表时间：
1962-01-01
影响因子：
15.9
通讯作者：
MELLEMGAARD, K
中科院分区：
文献类型：
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作者：
TYGSTRUP, N;ANDREASSEN, M;MELLEMGAARD, K
8例患者在夹闭肝动脉前和夹闭肝动脉约20分钟期间，通过测量肝血流量（磺溴酞法）和动脉、门静脉和肝静脉血的氧含量，用间接法测定肝动脉血流量。平均为肝血流量的35%，从9%到65%不等。动脉平均提供50[degree]/B的肝耗氧量，由于从门静脉血中提取更多的氧，在夹闭期间保持恒定。门静脉血流量在夹闭过程中无明显下降。内脏耗氧量中肝外耗氧量平均占30%。动脉、门静脉和肝静脉压力不受夹闭的影响。磺溴酞的肝脏提取增加，并且在肝动脉夹闭期间，肝脏中没有可测量的转氨酶释放，表明肝功能未受到影响。
The hepatic arterial blood flow was determined in 8 patients by an indirect method, based on measurement of hepatic blood flow (sulfobromophthalein-method) and oxygen content of arterial, portal venous and hepatic venous blood before and during clamping of the hepatic artery proper for about 20 minutes. On the average it was 35% of the hepatic blood flow, varying from 9 to 65%. The artery supplied averagely 50[degree]/b of the hepatic oxygen consumption, which remained constant during the clamping owing to a greater extraction of oxygen from the portal blood. The portal blood flow decreased insignificantly during the clamping. Averagely 30% of the splanchnic oxygen consumption was extra-hepatic. The arterial, portal venous and hepatic venous pressure was unaffected by the clamping. The hepatic extraction of sulfobromo-phthalein was increased, and there was no measurable release of transaminases from the liver during clamping of the hepatic artery, indicating that the liver function was not affected.