A review of the role of swine skeletal muscle in malignant hyperthermia.
A review of the role of swine skeletal muscle in malignant hyperthermia.
复制标题
猪骨骼肌在恶性高热中的作用综述。
DOI：
10.2527/jas1975.413779x
复制
发表时间：
1975
影响因子：
3.3
通讯作者：
D. G. Topel
中科院分区：
文献类型：
--
作者：
D. Campion;D. G. Topel
恶性高热综合征（MHS）是从肌浆Ca2+浓度足以刺激磷酸化酶激酶并间接刺激肌球蛋白ATP酶的点开始观察的。当线粒体利用高能中间体螯合Ca2+时，细胞内Ca2+浓度升高可能导致氧化磷酸化功能性解偶联。因此，ATP被消耗，ADP和无机磷的细胞水平增加，随着MHS的发展进一步刺激糖酵解。由于线粒体螯合Ca 2+，O2消耗量增加，除了温度的刺激作用外，这可能解释了观察到的O2消耗量增加。然而，当暴露于氟烷时，允许各种身体功能以异常的方式联合收割机产生我们所认为的恶性高热的触发机制仍然不清楚。(
The syndrome of malignant hyperthermia (MHS) has been visualized from the point at which sarcoplasmic Ca 2+ concentration becomes sufficient to stimulate phosphorylase kinase and, indirectly, myosin ATPase. Elevated l v 2+ e els of cellular Ca may cause a functional uncoupling of oxidative phosphorylation as the mitochondria utilize high energy intermediates to sequester Ca 2+. Consequently, ATP is consumed, and the cellular levels of ADP and inorganic phosphorus increases, further stimulating glycolysis as the MHS develops. As the mitochondria sequester Ca 2+, 02 consumption is increased and this, in addition to the stimulating effect of temperature, may explain the observed increase in O2 consumption. However, the triggering mechanisms that allow the various body functions, when exposed to halothane, to combine in an abnormal manner to produce what we recognize as malignant hyperthermia remain obscure. (