Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study.
Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study.
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简短交流：多中心艾滋病队列研究中的血浆淋巴细胞激活基因 3 和亚临床冠状动脉疾病。
DOI：
10.1089/aid.2021.0035
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发表时间：
2021
影响因子：
1.5
通讯作者：
Brown,ToddT
中科院分区：
文献类型：
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作者：
Sarkar,Sudipa;Haberlen,Sabina;Post,WendyS;Kelesidis,Theodoros;Wiley,Dorothy;Kingsley,Lawrence;Kim,Eun-Young;Palella,FrankJ;Witt,MalloryD;Budoff,MatthewJ;Rodriguez,Annabelle;Brown,ToddT
慢性炎症，包括HIV感染者（PWH），会提高淋巴细胞活化基因3（LAG 3）的免疫细胞表达;然而，低血浆LAG 3可预测一般人群中的心血管疾病（CVD）事件。LAG 3血浆水平、亚临床动脉粥样硬化、炎症和HIV感染之间的关联尚未得到很好的描述。我们在多中心艾滋病队列研究中检测了704名接受冠状动脉计算机断层扫描血管造影术的HIV阳性和阴性男性的血浆LAG 3。调整社会人口统计学和CVD危险因素后，HIV血清状态与LAG 3无关。当前吸烟状况和非裔美国人种族与较低的LAG 3相关，年龄和sTNFαRI浓度与较高的LAG 3相关。LAG 3与冠状动脉狭窄无关。因此，没有发现HIV血清状态的血浆LAG 3浓度的差异，并且没有观察到LAG 3与有和无HIV的男性中的亚临床冠状动脉粥样硬化之间的关联。
Chronic inflammation, including among people with HIV (PWH), elevates immune cell expression of lymphocyte activation gene 3 (LAG3); however, low plasma LAG3 predicts cardiovascular disease (CVD) events in the general population. The associations among LAG3 plasma levels, subclinical atherosclerosis, inflammation, and HIV infection have not been well described. We measured plasma LAG3 in 704 men with and without HIV from the multicenter AIDS cohort study, who underwent coronary computed tomography angiography. HIV serostatus was not independently associated with LAG3 after adjustment for sociodemographic and CVD risk factors. Current smoking status and African American race were associated with lower LAG3, and age and sTNFαRI concentration were associated with greater LAG3. LAG3 was not associated with coronary artery stenosis. Thus, no difference was found in plasma LAG3 concentration by HIV serostatus, and no association between LAG3 and subclinical coronary atherosclerosis in men with and without HIV was observed.