Depression in Parkinson's disease: Conceptual issues and clinical challenges
Depression in Parkinson's disease: Conceptual issues and clinical challenges
复制标题
DOI：
10.1177/0891988704267456
复制
发表时间：
2004-09-01
影响因子：
2.6
通讯作者：
Leentjens, AFG
中科院分区：
文献类型：
--
作者：
Leentjens, AFG
背景：抑郁症常伴有帕金森氏病(PD)，并可能对日常生活活动、认知表现和生活质量产生负面影响。由于这两种疾病之间的症状重叠，可能很难识别帕金森病患者的抑郁。此外，部分共享的病理生理学可能使治疗抑郁症状不影响运动或认知功能变得困难。目的：综述帕金森病患者抑郁的流行病学、病因学、病理生理学及治疗现状。方法：结合近期研究和相关文献进行讨论。结论：不仅在概念上，而且在病因、病理生理学和治疗方面，帕金森病与抑郁的关系仍然是一个挑战。仍然有许多问题需要回答。在治疗领域，大型安慰剂对照试验是必要的，以评估抗抑郁治疗的有效性，并允许制定循证指南。
Background: Depression frequently accompanies Parkinson's disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared pathophysiology may make it difficult to treat depressive symptoms without influencing motor or cognitive function. Objective: To review the current knowledge of the epidemiology, etiology, pathophysiology, and treatment of depression in patients with Parkinson's disease. Method: Discussion of recent studies and relevant literature. Conclusion: Not only conceptually but also in terms of etiology, pathophysiology, and treatment, the relationship between PD and depression remains a challenge. There are still many questions to be answered. In the therapeutic domain, large, placebo-controlled trials are necessary to evaluate the efficacy of antidepressant treatment and allow the development of evidence-based guidelines.