The second sensory area in humans: Evoked potential and electrical stimulation studies
The second sensory area in humans: Evoked potential and electrical stimulation studies
复制标题
人类的第二感觉区：诱发电位和电刺激研究
作者：
H. Lüders;R. Lesser;D. Dinner;J. Hahn;V. Salanga;H. Morris
一名来自右额叶病灶的顽固性癫痫患者接受了手术治疗评估。该评估是使用长期植入的 96 个不锈钢电极阵列进行的，这些电极间隔 1 厘米，覆盖肛周和额叶区域。体感诱发电位和硬膜下电极的电刺激定位了主要感觉手区域。在紧邻运动带面部区域之前的额下回记录了波形相同但幅度较低且潜伏期延长 2.4 ms 的诱发电位。对该区域进行电刺激会引起：（1）左臂和面部出现“麻痹”感； (2)抑制左手指、左手、舌头的快速交替运动； (3)左手或舌头无法维持强烈的随意肌收缩； (4)言语拘捕。这似乎是通过电刺激和诱发电位研究证明人类次级感觉区域的第一份报告。电刺激表明，次级感觉区与复杂运动控制的区域重叠，这表明次级感觉区为适当的运动整合提供了直接的感觉反馈信息。
A patient with intractable seizures originating from a right frontal focus was evaluated for surgical treatment. This evaluation was carried out using a chronically implanted array of 96 stainless steel electrodes 1 cm apart and covering the perirolandic and frontal areas. Somatosensory evoked potentials and electrical stimulation of the subdural electrodes localized the primary sensory hand area. Evoked potentials of identical waveform but of lower amplitude and 2.4 ms longer latency were recorded in the inferior frontal gyrus immediately anterior to the face area of the motor strip. Electrical stimulation of that area elicited: (1) a “paralyzing” feeling in the left arm and face; (2) inhibition of rapid alternating movements of left fingers, left hand, and tongue; (3) inability to maintain a strong voluntary muscle contraction of the left hand or tongue; and (4) speech arrest. This appears to be the first report of a secondary sensory area in humans demonstrated by both electrical stimulation and evoked potential studies. Electrical stimulation showed that the secondary sensory area overlapped an area of complex motor control, suggesting that the secondary sensory area provides direct sensory feedback information for appropriate motor integration.