8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress.
8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress.
复制标题
DOI：
10.1016/j.freeradbiomed.2010.05.008
复制
发表时间：
2010-08-15
影响因子：
7.4
通讯作者：
Boldogh, Istvan
中科院分区：
文献类型：
--
作者：
Radak, Zsolt;Boldogh, Istvan
关键词：
鸟嘌呤8-氧代-7，8-二氢鸟嘌呤（8-oxoG）的单电子氧化产物是基因组、线粒体和端粒DNA和RNA中丰富的损伤。它被认为是氧化应激的标志物，其优先在DNA螺旋、鸟嘌呤四链体和RNA分子中的鸟嘌呤链的5'端积累。8-与鸟嘌呤相比，oxoG具有较低的氧化电位，因此它对氧化/还原敏感，并且沿着其氧化还原产物，传统上被认为是主要的遗传毒性/致突变DNA碱基损伤。它不改变DNA双螺旋的结构，并且在DNA碱基切除修复途径期间被8-氧代鸟嘌呤DNA糖基化酶（OGG 1）特异性识别和切除。OGG 1缺失动物在其基因组中积累过量水平的8-oxoG，而它们不具有较短的寿命，也不表现出严重的病理症状，包括肿瘤形成。事实上，它们对炎症的抵抗力越来越强。在这里，我们解决了很少考虑的8-oxoG的意义，如在给定条件下，其在DNA和RNA中的最佳水平，正常细胞生理学的必要性，进化作用，软化DNA中氧化应激影响的能力，其修复的有害后果，以及其在转录起始和染色质松弛中的重要性。
The one-electron oxidation product of guanine 8-oxo-7,8-dihydroguanine (8-oxoG) is an abundant lesion in genomic, mitochondrial and telomeric DNA and RNA. It is considered to be a marker of oxidative stress that preferentially accumulates at the 5’ end of guanine strings in the DNA helix, guanine quadruplexes and in RNA molecules. 8-oxoG has a lower oxidation potential compared to guanine, thus it is susceptible to oxidation/reduction and along with its redox products, is traditionally considered to be a major genotoxic/mutagenic DNA base lesion. It does not change the architecture of the DNA double helix and it is specifically recognized and excised by 8-oxoguanine DNA glycosylase (OGG1) during the DNA base excision repair pathway. OGG1 null animals accumulate excess levels of 8-oxoG in their genome, while they do not have shorter lifespan, nor exhibit severe pathological symptoms including tumor formation. In fact they are increasingly resistant to inflammation. Here we address rarely considered significance of 8-oxoG such as its optimal level in the DNA and RNA in a given condition, essentiality for normal cellular physiology, evolutionary role, ability to soften the effects of oxidative stress in DNA, harmful consequences of its repair, as well as its importance in transcriptional initiation and chromatin relaxation.
登录
查看更多内容
影响因子：
5.3
作者：
Bacsi, Attila;Chodaczek, Grzegorz;Boldogh, Istvan
通讯作者：
Boldogh, Istvan
影响因子：
14.9
作者：
Chattopadhyay R;Wiederhold L;Szczesny B;Boldogh I;Hazra TK;Izumi T;Mitra S
通讯作者：
Mitra S
影响因子：
4.1
作者：
BOVERIS, A;CHANCE, B
通讯作者：
CHANCE, B
影响因子：
11.4
作者：
Charlet-Berguerand, Nicolas;Feuerhahn, Sascha;Egly, Jean Marc
通讯作者：
Egly, Jean Marc
DOI：
10.1007/978-1-60327-029-8_17
发表时间：
2010-01-01
期刊：
FREE RADICALS AND ANTIOXIDANT PROTOCOLS, SECOND EDITION
影响因子：
--
作者：
Calabrese, Vittorio;Cornelius, Carolin;Butterfield, D. Allan
通讯作者：
Butterfield, D. Allan